五甲基-1,3-二乙氰基苯合成路线 （共 8 条）
反应条件
sodium hydride in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
Jackson, Toby; Woo, L. W. Lawrence; Trusselle, Melanie N.; Chander, Surinder K.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 18 p. 2940 - 2952
反应条件
1: (3-cyanomethyl-5-methyl-phenyl)-acetonitrile With potassium tert-butylate in N,N-dimethyl-formamide T=15 - 20°C; 4 - 5 h; 2: methyl iodide in N,N-dimethyl-formamide 1 h;
参考文献
WO2007/105231 A1, ;
Page/Page column 5 ;
反应条件
sodium hydride in N,N-dimethyl-formamide T=0°C; Inert atmosphere;
参考文献
Mei, Yu-Hua; Luo, Yu; Lu, Wei
Organic Preparations and Procedures International, 2008 , vol. 40, # 5 p. 487 - 489
反应条件
bis(η3-allyl-μ-chloropalladium(II)); 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1,3,5-trimethyl-benzene T=20 - 140°C; 3.16667 h; Inert atmosphereSealed tube; chemoselective reaction;
参考文献
Shang, Rui; Ji, Dong-Sheng; Chu, Ling; Fu, Yao; Liu, Lei
Angewandte Chemie - International Edition, 2011 , vol. 50, # 19 p. 4470 - 4474
反应条件
in N,N-dimethyl-formamide T=-10 - -5°C; 0.75 h; Product distribution / selectivity;
参考文献
WO2009/10991 A2, ;
Page/Page column 9; 10; 11; 11-12; 12; 13 ;
反应条件
N-bromosuccinmide; dibenzoyl peroxide in N-methyl-acetamide; tetrachloromethane; water
参考文献
US4935437 A1, ;
US 4935437 A
反应条件
1.1: 1,3-dibromo-5,5-dimethyl-hydantoin / 2,2'-azo-bisisobutyronitrile / cyclohexane / 4 h / 25 - 85 °C 2.1: isopropyl alcohol / 5 h / 80 - 85 °C 3.1: hydrogenchloride; sodium nitrite / water / 8 h / -5 - 20 °C 3.2: 4 h / 5 - 25 °C View Scheme
反应条件
N-bromosuccinmide; dibenzoyl peroxide in tetrachloromethane 2 - 2.5 h; Heating / reflux;
参考文献
Glenmark Pharmaceuticals Limited
Patent: US2006/189670 A1, 2006 ;
Location in patent: Page/Page column 5; 7 ;
