2-[3-(1-氰基-1-甲基乙基)-5-(羟甲基)苯基]-2-甲基丙腈合成路线 （共 4 条）
反应条件
lithium borohydride in tetrahydrofuran 3 h; Heating;
参考文献
Jackson, Toby; Woo, L. W. Lawrence; Trusselle, Melanie N.; Chander, Surinder K.; Purohit, Atul; Reed, Michael J.; Potter, Barry V. L.
Organic and Biomolecular Chemistry, 2007 , vol. 5, # 18 p. 2940 - 2952
反应条件
1: 2-[3-(cyano-dimethyl-methyl)-5-hydroxymethyl-phenyl]-2-methyl-propionitrile With sodium hydride in tetrahydrofuran T=70°C; 0.5 h; 2: 1-(4-toluenesulfonyl)-1H-1,2,4-triazole in isobutyramide T=20°C; 0.333333 h; Product distribution / selectivity;
参考文献
US2008/76933 A1, ;
Page/Page column 5 ;
反应条件
pyridinium chlorochromate in dichloromethane
参考文献
Imperial Chemical Industries plc
Patent: US4935437 A1, 1990 ;
US 4935437 A
反应条件
thionyl chloride in N,N-dimethyl acetamide T=15 - 35°C; 1.75 - 3.25 h;
参考文献
Pis, Jaroslav; Smrz, Rudolf
Patent: US2007/281982 A1, 2007 ;
Location in patent: Page/Page column 6 ;
