(S)-o-[(2,2-二甲基-1,3-二氧杂烷-4-基)甲基]-羟胺盐酸盐合成路线 (共 4 条)
反应条件
1: 69 percent / Ph3P, diethyl azodicarboxylate (DEAD) / tetrahydrofuran / 18 h / 20 °C 2: 91 percent / methylhydrazine / CH2Cl2 / 1 h / 20 °C View Scheme
参考文献
Bailey, Stuart; Harnden, Michael R.; Jarvest, Richard L.; Parkin, Ann; Boyd, Malcolm R.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 1 p. 57 - 65
参考文献
Barrett, Stephen Douglas; Biwersi, Cathlin Marie; Chen, Michael Huai Gu; Kaufman, Michael David; Tecle, Haile; Warmus, Joseph Scott
Patent: US2004/54172 A1, 2004 ;
反应条件
1: With 1,1'-carbonyldiimidazole in ethanol; water; toluene; acetonitrile T=17 - 27°C; 7.5 h; 2: With hydrogenchloride in water; toluene; acetonitrile 20.0833 h; 3: in ethanol; water; toluene T=0 - 45°C;
参考文献
US2005/85550 A1, ;
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