2-丁基-4-氯-1-{[2'-(1-三苯甲基-1H-四唑-5-基)-4-联苯基]甲基}-1H-咪唑-5-甲醛合成路线 （共 7 条）
反应条件
sodium hydroxide; tetrabutylammomium bromide in n-butyl chloride; water T=25 - 50°C; 32 h;
参考文献
WO2006/38223 A1, ;
Page/Page column 6-7 ;
反应条件
potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in water; ethyl acetate; N,N-dimethyl-formamide; toluene T=85°C; 48 h; Product distribution / selectivity;
参考文献
EP1833801 B1, ;
Page/Page column 13 ;
反应条件
potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran 72 h; Heating / reflux; Product distribution / selectivity;
参考文献
EP1833801 B1, ;
Page/Page column 13 ;
反应条件
manganese(IV) dioxide in dichloromethane; 1,2-dichloro-ethane
参考文献
US5298517 A1, ;
US 5298517 A
反应条件
potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran 72 h; Heating / reflux; Product distribution / selectivity;
参考文献
EP1833801 B1, ;
Page/Page column 13; 14 ;
反应条件
potassium phosphate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in tetrahydrofuran 48 h; Heating / reflux; Product distribution / selectivity;
参考文献
EP1833801 B1, ;
Page/Page column 13 ;
反应条件
1: With sodium tetrahydroborate in n-butyl chloride T=25 - 45°C; 2: With methanol in n-butyl chloride T=40 - 45°C; 5.75 h; 3: With water in n-butyl chloride T=40 - 45°C;
参考文献
WO2006/38223 A1, ;
Page/Page column 6-7 ;
