1: 75 percent / pyridine / 24 h / 4 °C 2: 59 percent / tetrabutylammonium fluoride / acetonitrile / 72 h / Heating 3: H2 / 10percent Pd-C / acetic acid / 24 h / 2587.7 Torr / Ambient temperature 4: pyridine / 24 h / Ambient temperature 5: 85 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 44 h / 50 °C 6: 32 percent / 1,2-dichloro-ethane / 24 h / Ambient temperature 7: 88 percent / H2 / Pd-C / methanol / 1 h / Ambient temperature 8: 2.) M NaOH, 3.) M LiOH / 1.) pyridine, 37 deg C, 24 h; 2.) water, room temp., 1 h View Scheme

1: pyridine / 24 h / Ambient temperature 2: 85 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 44 h / 50 °C 3: 32 percent / 1,2-dichloro-ethane / 24 h / Ambient temperature 4: 88 percent / H2 / Pd-C / methanol / 1 h / Ambient temperature 5: 2.) M NaOH, 3.) M LiOH / 1.) pyridine, 37 deg C, 24 h; 2.) water, room temp., 1 h View Scheme

1: H2 / 10percent Pd-C / acetic acid / 24 h / 2587.7 Torr / Ambient temperature 2: pyridine / 24 h / Ambient temperature 3: 85 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 44 h / 50 °C 4: 32 percent / 1,2-dichloro-ethane / 24 h / Ambient temperature 5: 88 percent / H2 / Pd-C / methanol / 1 h / Ambient temperature 6: 2.) M NaOH, 3.) M LiOH / 1.) pyridine, 37 deg C, 24 h; 2.) water, room temp., 1 h View Scheme

1: 59 percent / tetrabutylammonium fluoride / acetonitrile / 72 h / Heating 2: H2 / 10percent Pd-C / acetic acid / 24 h / 2587.7 Torr / Ambient temperature 3: pyridine / 24 h / Ambient temperature 4: 85 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 44 h / 50 °C 5: 32 percent / 1,2-dichloro-ethane / 24 h / Ambient temperature 6: 88 percent / H2 / Pd-C / methanol / 1 h / Ambient temperature 7: 2.) M NaOH, 3.) M LiOH / 1.) pyridine, 37 deg C, 24 h; 2.) water, room temp., 1 h View Scheme

1: 32 percent / 1,2-dichloro-ethane / 24 h / Ambient temperature 2: 88 percent / H2 / Pd-C / methanol / 1 h / Ambient temperature 3: 2.) M NaOH, 3.) M LiOH / 1.) pyridine, 37 deg C, 24 h; 2.) water, room temp., 1 h View Scheme

1: 85 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 44 h / 50 °C 2: 32 percent / 1,2-dichloro-ethane / 24 h / Ambient temperature 3: 88 percent / H2 / Pd-C / methanol / 1 h / Ambient temperature 4: 2.) M NaOH, 3.) M LiOH / 1.) pyridine, 37 deg C, 24 h; 2.) water, room temp., 1 h View Scheme

1: 88 percent / H2 / Pd-C / methanol / 1 h / Ambient temperature 2: 2.) M NaOH, 3.) M LiOH / 1.) pyridine, 37 deg C, 24 h; 2.) water, room temp., 1 h View Scheme

lithium hydroxide; sodium hydroxide 1.) pyridine, 37 deg C, 24 h; 2.) water, room temp., 1 h; Yield given. Multistep reaction;