1-(4-甲氧基苯基)-1-环戊腈合成路线 （共 5 条）
反应条件
sodium hydroxide T=110 - 120°C; 12 h;
参考文献
Mndzhoyan, Sh. L.; Tsinker, M. G.; Ovakimyan, A. R.; Ter-Zakharyan, Yu. Z.; Oganyan, Sh. G.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 3 p. 179 - 184
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 3 p. 53 - 59
反应条件
potassium hydroxide in diethylene glycol 6 h; Heating;
参考文献
Mndzhoyan, Sh. L.; Tsinker, M. G.; Ovakimyan, A. R.; Ter-Zakharyan, Yu. Z.; Oganyan, Sh. G.
Pharmaceutical Chemistry Journal, 1980 , vol. 14, # 3 p. 179 - 184
Khimiko-Farmatsevticheskii Zhurnal, 1980 , vol. 14, # 3 p. 53 - 59
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C; 16 h;
参考文献
H. Lundbeck A/S; Kilburn, John Paul; Rasmussen, Lars Kyhn; Jessing, Mikkel; Eldemenky, Eman Mohammed; Chen, Bin; Jiang, Yu; Hopper, Allen T.
Patent: US2014/107340 A1, 2014 ;
Location in patent: Paragraph 0254 ;
反应条件
1: 29 percent / KOH / bis-(2-hydroxy-ethyl) ether / 144 h / Heating
2: 1 M BH3*THF / tetrahydrofuran / 2 h / Ambient temperature
View Scheme
参考文献
Roberts, Donald D.; Arant, Mark E.
Journal of Organic Chemistry, 1994 , vol. 59, # 21 p. 6464 - 6469
