3,6-二甲氧基-2-硝基苯甲醛合成路线 （共 14 条）
反应条件
1: 84 percent / K2CO3 / dimethylformamide / 2 h / 60 - 65 °C
2: KOH / ethanol / 0.5 h / Ambient temperature
3: Cu2O, quinoline / 8 h / Heating
4: 59 percent / CAN / acetonitrile; H2O / 0.17 h / Ambient temperature
View Scheme
参考文献
Valderrama, Jaime A.; Valderrama, Claudio
Synthetic Communications, 1997 , vol. 27, # 12 p. 2143 - 2157
反应条件
1.1: AcOH; NaOAc / 5 h / Heating
2.1: H2; HCOONH4 / Pd/C / ethanol / 0.5 h / Heating
3.1: 82 percent / NaH / tetrahydrofuran / 4 h / 20 °C
4.1: n-BuLi / tetrahydrofuran; hexane / 2 h / -78 °C
4.2: 70 percent / tetrahydrofuran / -78 - 20 °C
5.1: 76 percent / ceric (IV) ammonium nitrate / acetonitrile; H2O / 0.5 h / 20 °C
View Scheme
参考文献
Mahboobi, Siavosh; Sellmer, Andreas; Eichhorn, Emerich; Beckers, Thomas; Fiebig, Heinz-Herbert; Kelter, Gerhard
European Journal of Medicinal Chemistry, 2005 , vol. 40, # 1 p. 85 - 92
反应条件
1: 70 percent / NH4OAc / 1 h / Heating
2: 84 percent / HCO2NH4 / Pd/C / ethanol / 1 h / Heating
3: 96 percent / POCl3 / 1.5 h / 0 °C
4: 76 percent / NH4OAc / 1 h / Heating
5: LAH / CH2Cl2; diethyl ether / 1 h / 20 °C
View Scheme
参考文献
Beneteau, Valerie; Besson, Thierry
Tetrahedron Letters, 2001 , vol. 42, # 14 p. 2673 - 2676
参考文献
Rubenstein
Journal of the Chemical Society, 1925 , vol. 127, p. 2003
