1: 85 percent / trimethylsilyl trifluoromethanesulfonate / 1,2-dichloro-ethane / 44 h / 50 °C 2: 32 percent / 1,2-dichloro-ethane / 24 h / Ambient temperature 3: 88 percent / H2 / Pd-C / methanol / 1 h / Ambient temperature 4: 2.) M NaOH, 3.) M LiOH / 1.) pyridine, 37 deg C, 24 h; 2.) water, room temp., 1 h View Scheme

Multi-step reaction with 5 steps 1: 96 percent / dimethylformamide / 48 h / 160 - 165 °C2: 92 percent / CH3ONa / acetic acid / 7 h / Heating3: 82 percent / N,N-diethylaminosulfur trifluoride, pyridine / CH2Cl2 / -20 deg C, 30 min, 2) r.t., 3h4: 70 percent / H2 / Pd-C (10percent) / acetic acid / 48 h5: 73 percent / pyridine