4-氯-2-氟-7H-吡咯并[2,3-d]嘧啶合成路线 (共 1 条)
反应条件
1: With pyridine; tert.-butylnitrite; hydrogen fluoride T=-60 - -40°C; Teflon bottle; 2: With potassium carbonate in chloroform; water Cooling;
参考文献
BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; CHAND, Pooran; KOTIAN, Pravin, L.; KUMAR, V., Satish
Patent: WO2010/14930 A2, 2010 ;
Location in patent: Page/Page column 57-58 ;
WO 2010/014930 A2