7,8-二氢-2-甲氧基-6(5h)-喹啉酮合成路线 （共 9 条）
反应条件
1: With silver carbonate in chloroform T=20°C; Darkness; 2: With hydrogenchloride in chloroform; water; acetone Reflux; 3: With sodium hydrogencarbonate in water
参考文献
Ding, Xiao-Hua; Li, Xiang; Liu, Dan; Cui, Wei-Chen; Ju, Xuan; Wang, Shaozhong; Yao, Zhu-Jun
Tetrahedron, 2012 , vol. 68, # 31 p. 6240 - 6248
反应条件
phosphoric acid in water T=20 - 80°C; 3 h;
参考文献
Tudhope, Stephen R.; Bellamy, Julie A.; Ball, Anthony; Rajasekar, Dewakar; Azadi-Ardakani, Manouchehr; Meera, Harihara Subramanian; Gnanadeepam, Jesudoss Mercy; Saiganesh, Ramanathan; Gibson, Frank; He, Linli; Behrens, Carl H.; Underiner, Gail; Marfurt, Judith; Favre, Nathalie
Organic Process Research and Development, 2012 , vol. 16, # 4 p. 635 - 642
反应条件
1: 65 percent / NH3 / methanol / 8 h / 100 °C 2: 95 percent / Ag2CO3 / CHCl3 / 2.5 h / Heating 3: 90 percent / HCl / acetone; H2O / 3 h / Heating View Scheme
参考文献
Kozikowski; Xia; Reddy; Tuckmantel; Hanin; Tang
Journal of Organic Chemistry, 1991 , vol. 56, # 15 p. 4636 - 4645
反应条件
1: NH3 / methanol / 5 h / 100 °C 2: 31 percent / Ag2CO3 / CHCl3 / 72 h / 25 °C 3: 94 percent / 5percent aq. HCl / acetone / 15 h / Heating View Scheme
参考文献
Kozikowski
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 1 p. 97 - 105
反应条件
1: 95 percent / Ag2CO3 / CHCl3 / 2.5 h / Heating 2: 90 percent / HCl / acetone; H2O / 3 h / Heating View Scheme
参考文献
Kozikowski; Xia; Reddy; Tuckmantel; Hanin; Tang
Journal of Organic Chemistry, 1991 , vol. 56, # 15 p. 4636 - 4645
反应条件
1: H2 / 20percent Pd(OH)2 on carbon / acetic acid / 36 h / Ambient temperature 2: Ag2CO3 / CHCl3 / Ambient temperature 3: 85 percent / 5percent HCl / acetone / Heating View Scheme
参考文献
Kozikowski
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 1 p. 97 - 105
反应条件
1: 2) AcOH / 1) MeOH, 2h, reflux 2) DMF, 2h, reflux 2: 92 percent / Ag2CO3 / CHCl3 3: 85 percent / 5percent HCl / acetone / Heating View Scheme
参考文献
Kozikowski
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 1 p. 97 - 105
反应条件
2: 2) AcOH / 1) MeOH, 2h, reflux 2) DMF, 2h, reflux 3: 92 percent / Ag2CO3 / CHCl3 4: 85 percent / 5percent HCl / acetone / Heating View Scheme
参考文献
Kozikowski
Journal of Heterocyclic Chemistry, 1990 , vol. 27, # 1 p. 97 - 105
反应条件
potassium hydride 3 h; Heating;
参考文献
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Patent: EP1167354 A2, 2002 ;
Location in patent: Page 16 ;
