(3S)-3-氨基-3-苯基丙酸叔丁酯合成路线 （共 12 条）
反应条件
hydrogen; acetic acid; palladium dihydroxide in methanol; water T=20°C; P=760.051 Torr; 24 h;
参考文献
Davies, Stephen G.; Mulvaney, Andrew W.; Russell, Angela J.; Smith, Andrew D.
Tetrahedron Asymmetry, 2007 , vol. 18, # 13 p. 1554 - 1566
反应条件
1: With N-iodo-succinimide in dichloromethane T=20°C; 1 h; Inert atmosphere; 2: With water; sodium hydrogencarbonate; sodium thiosulfate in dichloromethane T=20°C; Inert atmosphere;
参考文献
Organic Letters, , vol. 10, # 13 p. 2653 - 2656
反应条件
1: 96 percent / BuLi / tetrahydrofuran / 1.) -78 deg C to 0 deg C, 10 min, 2.) -78 deg C, 1.5 h 2: 75 percent / H2 / Pd(OH)2 / methanol / 48 h / 5320 Torr / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 17 p. 2635 - 2643
反应条件
hydrogen; palladium on activated charcoal in methanol 5 h; Ambient temperature;
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 7 p. 1497 - 1503
反应条件
hydrogen; palladium dihydroxide in ethanol P=2850.23 Torr; 72 h; Title compound not separated from byproducts;
参考文献
Helvetica Chimica Acta, , vol. 85, # 1 p. 161 - 167
反应条件
1: benzene / 0.5 h / Heating 2: hydrogen / 10 percent Pd/charcoal / methanol / 5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 7 p. 1497 - 1503
反应条件
1: 73 percent / Et3N / 12 h / 90 °C 2: BuLi / tetrahydrofuran; hexane / 1 h 3: H2 / Pd(OH)2/C / ethanol / 72 h / 2850.23 Torr View Scheme
参考文献
Helvetica Chimica Acta, , vol. 85, # 1 p. 161 - 167
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 96 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: 88 percent / tetrahydrofuran; hexane / 3 h / -78 °C 3.1: 91 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 13 p. 1554 - 1566
反应条件
1.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 1.2: 96 percent / tetrahydrofuran; hexane / -78 - 20 °C 2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C 2.2: 88 percent / tetrahydrofuran; hexane / 3 h / -78 °C 3.1: 91 percent / H2; acetic acid / Pd(OH)2/C / methanol; H2O / 24 h / 20 °C / 760.05 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 18, # 13 p. 1554 - 1566
反应条件
hydrogenchloride in diethyl ether; ethanol T=20°C; 1 h;
参考文献
Synlett, , # 6 p. 991 - 993
