6-氯-1H-吡唑并[4,3-c]吡啶合成路线 （共 6 条）
反应条件
N-ethyl-N,N-diisopropylamine; hydrazine in N,N-dimethyl acetamide T=80°C; 4 h;
参考文献
MERCK SHARP and DOHME CORP.; LYCERA CORPORATION; AICHER, Thomas; BARR, Kenneth; LAPOINTE, Blair; SIMOV, Vladimir; STEIN, Karin; THOMAS, William; TOOGOOD, Peter; VAN HUIS, Chad; WHITE, Catherine
Patent: WO2013/169704 A2, 2013 ;
Location in patent: Paragraph 0232 ;
反应条件
trichlorophosphate 3 h; Heating / reflux;
参考文献
EP1772454 A1, ;
Page/Page column 63 ;
EP 1772454 A1
反应条件
1: manganese(IV) oxide / chloroform / 12 h / 75 °C 2: hydrazine; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 4 h / 80 °C View Scheme
反应条件
1: sodium tetrahydroborate; methanol / tetrahydrofuran / 2 h 2: manganese(IV) oxide / chloroform / 12 h / 75 °C 3: hydrazine; N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 4 h / 80 °C View Scheme
反应条件
p-toluenesulfonyl chloride in 1,4-dioxane T=110°C;
参考文献
F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; TSUI, Vickie, H.; WANG, Xiaojing
Patent: WO2014/1377 A1, 2014 ;
Location in patent: Page/Page column 121; 122 ;
反应条件
methanesulfonic acid in tetrahydrofuran; dichloromethane; ethyl acetate
参考文献
Incyte Corporation; Zhuo, Jincong; Xu, Meizhong; Qian, Ding-Quan
Patent: US2014/171405 A1, 2014 ;
Location in patent: Page/Page column ;
