4-氯-2-甲基-6-硝基喹啉合成路线 （共 9 条）
反应条件
trichlorophosphate in water 0.5 h; RefluxInert atmosphere;
参考文献
Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 419 - 434
反应条件
in trichlorophosphate
参考文献
Bender, Steven Lee; Bhumralkar, Dilip; Collins, Michael Raymond; Cripps, Stephen James; Deal, Judith Gail; Jia, Lei; Nambu, Mitchell David; Palmer, Cynthia Louise; Peng, Zhengwei; Varney, Michael David
Patent: US2002/103203 A1, 2002 ;
反应条件
1: sulfuric acid / 1,2,3,4-tetrahydro-naphthalene / 1 h / 150 - 210 °C / |Inert atmosphere 2: trichlorophosphate / water / 0.5 h / |Reflux; |Inert atmosphere View Scheme
参考文献
Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 419 - 434
反应条件
phosphorus pentachloride; trichlorophosphate
参考文献
Kermack; Weatherhead
Journal of the Chemical Society, 1939 , p. 563,565
反应条件
sulfuric acid; potassium nitrate
参考文献
Halcrow; Kermack
Journal of the Chemical Society, 1945 , p. 415
反应条件
1: sulfuric acid; nitric acid / 0 °C 2: phosphoryl chloride View Scheme
参考文献
Adams; Hey
Journal of the Chemical Society, 1949 , p. 3185,3187
反应条件
1: diphenyl ether / Beim Erhitzen auf Siedetemperatur 2: sulfuric acid; nitric acid / 0 °C 3: phosphoryl chloride View Scheme
参考文献
Adams; Hey
Journal of the Chemical Society, 1949 , p. 3185,3187
反应条件
1: sodium azide / N,N-dimethyl-formamide / 2 h / 100 °C / |Inert atmosphere
2: triphenylphosphine / tetrahydrofuran / 0.33 h / 20 °C / |Inert atmosphere
3: pyridine / 1 h / 60 °C / |Inert atmosphere
4: ammonium formate; 5 palladium on charcoal / methanol / 20 h / 20 °C / |Inert atmosphere
5: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 16 h / 20 °C / |Inert atmosphere
6: dichloromethane
View Scheme
参考文献
Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 419 - 434
反应条件
1: sodium azide / N,N-dimethyl-formamide / 2 h / 100 °C / |Inert atmosphere
2: triphenylphosphine / tetrahydrofuran / 0.33 h / 20 °C / |Inert atmosphere
View Scheme
参考文献
Williams, John D.; Khan, Atiyya R.; Cardinale, Steven C.; Butler, Michelle M.; Bowlin, Terry L.; Peet, Norton P.
Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 419 - 434
