(2S)-N-(1-环己基-3,4-二羟基-5-吗啉-4-基戊基)-2-[[2-(乙基磺酰基甲基)-3-萘-1-基丙酰]氨基]己酰胺合成路线 （共 13 条）
反应条件
1: 1) n-BuLi / 1) 1,2-dimethoxyethane
2: 100 percent / H2 / Raney-Ni
3: HCl
4: NaH / dimethylformamide
5: HCl, AcOH, H2O
6: 90 percent / NaBH3CN
7: 43 percent / (PhO)2P(O)N3, Ph3P, diethylazodicarboxylate
8: H2 / Pd-black / 760 Torr
9: 70 percent / DPPA, Et3N
View Scheme
参考文献
Nakano, Masato; Atsuumi, Shugo; Koike, Yutaka; Tanaka, Seiichi; Funabashi, Hiroshi; et al.
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1569 - 1572
反应条件
2: 1) LDA
3: 73 percent / LiO2H
4: 87 percent / cyclohexene / Pd / ethanol / Heating
5: 95 percent / DCC, HOBT
6: 96 percent / pyridine
7: dimethylformamide / Ambient temperature
8: H2O2, NaWO4 / methanol
9: 99 percent / CF3CO2H / CH2Cl2
10: 70 percent / DPPA, Et3N
View Scheme
参考文献
Nakano, Masato; Atsuumi, Shugo; Koike, Yutaka; Tanaka, Seiichi; Funabashi, Hiroshi; et al.
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1569 - 1572
反应条件
1: NaH / dimethylformamide
2: HCl, AcOH, H2O
3: 90 percent / NaBH3CN
4: 43 percent / (PhO)2P(O)N3, Ph3P, diethylazodicarboxylate
5: H2 / Pd-black / 760 Torr
6: 70 percent / DPPA, Et3N
View Scheme
参考文献
Nakano, Masato; Atsuumi, Shugo; Koike, Yutaka; Tanaka, Seiichi; Funabashi, Hiroshi; et al.
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1569 - 1572
反应条件
1: 87 percent / cyclohexene / Pd / ethanol / Heating
2: 95 percent / DCC, HOBT
3: 96 percent / pyridine
4: dimethylformamide / Ambient temperature
5: H2O2, NaWO4 / methanol
6: 99 percent / CF3CO2H / CH2Cl2
7: 70 percent / DPPA, Et3N
View Scheme
参考文献
Nakano, Masato; Atsuumi, Shugo; Koike, Yutaka; Tanaka, Seiichi; Funabashi, Hiroshi; et al.
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1569 - 1572
反应条件
1: 1) LDA
2: 73 percent / LiO2H
3: 87 percent / cyclohexene / Pd / ethanol / Heating
4: 95 percent / DCC, HOBT
5: 96 percent / pyridine
6: dimethylformamide / Ambient temperature
7: H2O2, NaWO4 / methanol
8: 99 percent / CF3CO2H / CH2Cl2
9: 70 percent / DPPA, Et3N
View Scheme
参考文献
Nakano, Masato; Atsuumi, Shugo; Koike, Yutaka; Tanaka, Seiichi; Funabashi, Hiroshi; et al.
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1569 - 1572
反应条件
1: HCl
2: NaH / dimethylformamide
3: HCl, AcOH, H2O
4: 90 percent / NaBH3CN
5: 43 percent / (PhO)2P(O)N3, Ph3P, diethylazodicarboxylate
6: H2 / Pd-black / 760 Torr
7: 70 percent / DPPA, Et3N
View Scheme
参考文献
Nakano, Masato; Atsuumi, Shugo; Koike, Yutaka; Tanaka, Seiichi; Funabashi, Hiroshi; et al.
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1569 - 1572
反应条件
1: 100 percent / H2 / Raney-Ni
2: HCl
3: NaH / dimethylformamide
4: HCl, AcOH, H2O
5: 90 percent / NaBH3CN
6: 43 percent / (PhO)2P(O)N3, Ph3P, diethylazodicarboxylate
7: H2 / Pd-black / 760 Torr
8: 70 percent / DPPA, Et3N
View Scheme
参考文献
Nakano, Masato; Atsuumi, Shugo; Koike, Yutaka; Tanaka, Seiichi; Funabashi, Hiroshi; et al.
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1569 - 1572
反应条件
1: 73 percent / LiO2H
2: 87 percent / cyclohexene / Pd / ethanol / Heating
3: 95 percent / DCC, HOBT
4: 96 percent / pyridine
5: dimethylformamide / Ambient temperature
6: H2O2, NaWO4 / methanol
7: 99 percent / CF3CO2H / CH2Cl2
8: 70 percent / DPPA, Et3N
View Scheme
参考文献
Nakano, Masato; Atsuumi, Shugo; Koike, Yutaka; Tanaka, Seiichi; Funabashi, Hiroshi; et al.
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1569 - 1572
反应条件
diphenyl-phosphinic acid; triethylamine
参考文献
Nakano, Masato; Atsuumi, Shugo; Koike, Yutaka; Tanaka, Seiichi; Funabashi, Hiroshi; et al.
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1569 - 1572
反应条件
1: 96 percent / pyridine
2: dimethylformamide / Ambient temperature
3: H2O2, NaWO4 / methanol
4: 99 percent / CF3CO2H / CH2Cl2
5: 70 percent / DPPA, Et3N
View Scheme
参考文献
Nakano, Masato; Atsuumi, Shugo; Koike, Yutaka; Tanaka, Seiichi; Funabashi, Hiroshi; et al.
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1569 - 1572
