(2S)-N-(1-环己基-3,4-二羟基-5-吗啉-4-基戊基)-2-[[2-(乙基磺酰基甲基)-3-萘-1-基丙酰]氨基]己酰胺合成路线 （共 13 条）
反应条件
1: dimethylformamide / Ambient temperature
2: H2O2, NaWO4 / methanol
3: 99 percent / CF3CO2H / CH2Cl2
4: 70 percent / DPPA, Et3N
View Scheme
参考文献
Nakano, Masato; Atsuumi, Shugo; Koike, Yutaka; Tanaka, Seiichi; Funabashi, Hiroshi; et al.
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1569 - 1572
反应条件
1: 95 percent / DCC, HOBT
2: 96 percent / pyridine
3: dimethylformamide / Ambient temperature
4: H2O2, NaWO4 / methanol
5: 99 percent / CF3CO2H / CH2Cl2
6: 70 percent / DPPA, Et3N
View Scheme
参考文献
Nakano, Masato; Atsuumi, Shugo; Koike, Yutaka; Tanaka, Seiichi; Funabashi, Hiroshi; et al.
Tetrahedron Letters, 1990 , vol. 31, # 11 p. 1569 - 1572
反应条件
hydrogenchloride; diphenyl phosphoryl azide; hydrogen; triethylamine; palladium
Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Atsuumi; Funabashi; Nakano; Koike; Tanaka; Harada; Matsuyama; Ikenaga; Morishima
Chemical and Pharmaceutical Bulletin, 1994 , vol. 42, # 2 p. 306 - 313
