4-氨基-6-氟-1(3H)-异苯并呋喃酮合成路线 （共 5 条）
反应条件
hydrogen; palladium 10 on activated carbon in ethyl acetate T=25°C; P=760.051 Torr; 12 h;
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
Location in patent: Page/Page column 122-123 ;
反应条件
1: nitric acid / sulfuric acid / 3.5 h / -5 - 0 °C 2: thionyl chloride / methanol / 16 h / 0 °C / Reflux 3: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / Reflux 4: 1,4-dioxane; water / 96 h / Reflux 5: hydrogen / palladium 10 on activated carbon / ethyl acetate / 12 h / 25 °C / 760.05 Torr View Scheme
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
反应条件
1: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / Reflux 2: 1,4-dioxane; water / 96 h / Reflux 3: hydrogen / palladium 10 on activated carbon / ethyl acetate / 12 h / 25 °C / 760.05 Torr View Scheme
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
反应条件
1: thionyl chloride / methanol / 16 h / 0 °C / Reflux 2: dibenzoyl peroxide; N-bromosuccinmide / tetrachloromethane / Reflux 3: 1,4-dioxane; water / 96 h / Reflux 4: hydrogen / palladium 10 on activated carbon / ethyl acetate / 12 h / 25 °C / 760.05 Torr View Scheme
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
反应条件
1: 1,4-dioxane; water / 96 h / Reflux 2: hydrogen / palladium 10 on activated carbon / ethyl acetate / 12 h / 25 °C / 760.05 Torr View Scheme
参考文献
BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHU, Daniel
Patent: WO2011/130661 A1, 2011 ;
