2-溴-3-甲基-3H-咪唑-4-羧酸甲酯合成路线 （共 5 条）
反应条件
N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile in tetrachloromethane T=60°C; 50 h;
参考文献
O'Connell, John F.; Parquette, Jonathan; Yelle, William E.; Wang, Wilhelm; Rapoport, Henry
Synthesis, 1988 , # 10 p. 767 - 771
反应条件
1: 64 percent / SOCl2 / 24 h / Heating 2: 83 percent / NBS / AIBN / CCl4 / 50 h / 60 °C View Scheme
参考文献
Synthesis, , # 10 p. 767 - 771
反应条件
1: 95 percent / Ac2O / 4 h / 100 °C 2: 64 percent / SOCl2 / 24 h / Heating 3: 83 percent / NBS / AIBN / CCl4 / 50 h / 60 °C View Scheme
参考文献
Synthesis, , # 10 p. 767 - 771
反应条件
1: 81 percent / aq. NaOH / 2 h / Heating 2: 95 percent / Ac2O / 4 h / 100 °C 3: 64 percent / SOCl2 / 24 h / Heating 4: 83 percent / NBS / AIBN / CCl4 / 50 h / 60 °C View Scheme
参考文献
Synthesis, , # 10 p. 767 - 771
反应条件
lithium hydroxide; water in tetrahydrofuran
T=20°C; 2.5 h;
参考文献
Wyeth
Patent: US2009/23707 A1, 2009 ;
Location in patent: Page/Page column 41 ;
US 20090023707 A1
