3-叔丁基二甲基甲硅烷基-2-丙炔-1-醇合成路线 （共 14 条）
反应条件
toluene-4-sulfonic acid in methanol Ambient temperature;
参考文献
Le Bideau; Gilloir; Nilsson; Aubert; Malacria
Tetrahedron, 1996 , vol. 52, # 21 p. 7487 - 7510
反应条件
1: propargyl alcohol With ethylmagnesium bromide in tetrahydrofuran 2: tert-butyldimethylsilyl chloride in tetrahydrofuran 2 h; Heating;
参考文献
Mohamed, Mustafa; Brook, Michael A.
Helvetica Chimica Acta, 2002 , vol. 85, # 12 p. 4165 - 4181
反应条件
1: 1.) n-BuLi / 1.) THF, hexane, -20 deg C, 1 h, 2.) THF, hexane, RT, overnight 2: conc. HCl / methanol / 2 h / Ambient temperature View Scheme
参考文献
Synthesis, , # 11 p. 1315 - 1320
反应条件
n-butyllithium Alkylation; hydroxymethylation;
参考文献
Tetrahedron Letters, , vol. 40, # 43 p. 7605 - 7609
反应条件
1: ethyl bromide With magnesium in tetrahydrofuran 2: dimethyl(1,1-dimethylethyl)(2-propynyloxy)silane in tetrahydrofuran 9 h; Heating;
参考文献
Medvedeva; Novokshonov; Mareev; Borisova
Russian Journal of Organic Chemistry, 2003 , vol. 39, # 3 p. 336 - 339
反应条件
hydrogenchloride in methanol 2 h; Ambient temperature;
参考文献
Synthesis, , # 11 p. 1315 - 1320
反应条件
n-butyllithium; pyridinium p-toluenesulfonate 1) THF, 20 deg C, 2 h, 2) MeOH, 20 deg C, 1 h; Yield given. Multistep reaction;
参考文献
Tetrahedron Letters, , vol. 33, # 30 p. 4349 - 4352
参考文献
Tetrahedron Letters, , vol. 34, # 17 p. 2823 - 2826
反应条件
o-nitrobenzenesulfonyl hydrazide; triphenylphosphine; diethylazodicarboxylate 1.) THF, -15 deg C, 10 min, 2.) THF, from -15 to 23 deg C; Yield given. Multistep reaction;
参考文献
Myers, Andrew G.; Zheng, Bin
Journal of the American Chemical Society, 1996 , vol. 118, # 18 p. 4492 - 4493
反应条件
1: CH3MgCl / 1.) THF, 0 - 10 deg C, 1.25 h; 0 deg C, 30 min., 2.) -70 deg C --> room temp., 2.5 h 2: 1.) CuBr, LiBr / 1.) THF, -50 deg C; 2.) -70 deg C --> room temp., 2.5 h 3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 40 min., 2.) -78 deg C --> room temp., 2.5 h View Scheme
参考文献
Danheiser, Rick L.; Stoner, Eric J.; Koyama, Hiroo; Yamashita, Dennis S.; Klade, Carrie A.
Journal of the American Chemical Society, 1989 , vol. 111, # 12 p. 4407 - 4413
