三甲基硅烷基 2-(氟磺酰基)二氟乙酸酯合成路线 （共 16 条）
反应条件
1: With sodium carbonate; 1,3-bis(2,4,6-trimethylphenyl)imidazolinium chloride in toluene
T=100°C; 1 h;
2: With 2,3-dicyano-5,6-dichloro-p-benzoquinone in toluene
T=100°C;
参考文献
Fuchibe, Kohei; Koseki, Yuta; Sasagawa, Hisashi; Ichikawa, Junji
Chemistry Letters, 2011 , vol. 40, # 10 p. 1189 - 1191
反应条件
Br(1-)*C21H26N3S(1+); sodium carbonate in toluene
T=80°C; 0.3 h;
参考文献
Fuchibe, Kohei; Koseki, Yuta; Aono, Tatsuya; Sasagawa, Hisashi; Ichikawa, Junji
Journal of Fluorine Chemistry, 2012 , vol. 133, p. 52 - 60
反应条件
1: 3-bromo-benzaldehyde With NAF; triphenylphosphine in ethyl acetate
T=90°C; Wittig Olefination; 0.0166667 h; Schlenk techniqueInert atmosphere;
2: trimethylsilyl-2,2-difluoro-2-(fluorosulfonyl) acetate in ethyl acetate
T=90°C; 1 h; Schlenk techniqueInert atmosphere;
参考文献
Zheng, Jian; Lin, Jin-Hong; Cai, Ji; Xiao, Ji-Chang
Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15261 - 15266
反应条件
1: 4-bromo-benzaldehyde With NAF; triphenylphosphine in ethyl acetate
T=90°C; Wittig Olefination; 0.0166667 h; Schlenk techniqueInert atmosphere;
2: trimethylsilyl-2,2-difluoro-2-(fluorosulfonyl) acetate in ethyl acetate
T=90°C; 1 h; Schlenk techniqueInert atmosphere; SolventTemperatureTimeConcentration;
参考文献
Zheng, Jian; Lin, Jin-Hong; Cai, Ji; Xiao, Ji-Chang
Chemistry - A European Journal, 2013 , vol. 19, # 45 p. 15261 - 15266
参考文献
Daiichi Sankyo Company, Limited
Patent: EP1908466 A1, 2008 ;
Location in patent: Page/Page column 90 ;
反应条件
NAF in diethylene glycol dimethyl ether
T=124°C; 1 h;
参考文献
Xu, Wei; Chen, Qing-Yun
Journal of Organic Chemistry, 2002 , vol. 67, # 26 p. 9421 - 9427
