2-羟基-1-甲基-6-苯基咪唑并[4,5-b]吡啶合成路线 （共 5 条）
反应条件
acetic acid 2 h; Reflux;
参考文献
Bergman, Jan
Tetrahedron Letters, 2009 , vol. 50, # 40 p. 5631 - 5632
反应条件
trifluoroacetic acid in dichloromethane T=20°C; 0.5 h;
参考文献
Choi, Jun Yong; Plummer, Mark S.; Starr, Jeremy; Desbonnet, Charlene R.; Soutter, Holly; Chang, Jeanne; Miller, J. Richard; Dillman, Keith; Miller, Alita A.; Roush, William R.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 852 - 870
反应条件
1: pyridine / tetrahydrofuran / 12 h / 0 - 20 °C 2: lithium aluminium tetrahydride / diethyl ether / 18.25 h / 0 - 20 °C 3: tetrahydrofuran; toluene / 5 h / 20 - 100 °C 4: triethylamine / dichloromethane / 16 h / 20 °C 5: tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate; tri-cyclo-hexyl-phosphine / 1,4-dioxane / 1 h / 100 °C / Microwave irradiation 6: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 2 p. 852 - 870
反应条件
1: tris-(dibenzylideneacetone)dipalladium(0); potassium phosphate; tri-cyclo-hexyl-phosphine / 1,4-dioxane / 1 h / 100 °C / Microwave irradiation 2: trifluoroacetic acid / dichloromethane / 0.5 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 2 p. 852 - 870
反应条件
1: With phosphorus pentachloride 2: With ammonia
参考文献
Bergman, Jan
Tetrahedron Letters, 2009 , vol. 50, # 40 p. 5631 - 5632
