2,6-二氯-N-(1-甲基-1H-咪唑-4-基)嘧啶-4-胺合成路线 (共 2 条)
反应条件
1: 1-methyl-4-nitroimidazole With hydrogen; palladium 10 on activated carbon in ethanol
P=760.051 Torr; 3 h;
2: 2,4,6-trichloro-pyrimidine With triethylamine
T=0 - 20°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; ALMEIDA, Lynsie; CHUAQUI, Claudio, Edmundo; GUAN, Amy; IOANNIDIS, Stephanos; LAMB, Michelle; PENG, Bo; SU, Qibin
Patent: WO2010/20810 A1, 2010 ;
Location in patent: Page/Page column 66-67 ;
WO 2010/020810 A1
反应条件
triethylamine in ethanol
T=0 - 25°C;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED; CHUAQUI, Claudio, Edmundo; HUANG, Shan; IOANNIDIS, Stephanos; SHI, Jie; SU, Mei; SU, Qibin
Patent: WO2010/38060 A1, 2010 ;
Location in patent: Page/Page column 87 ;
WO 2010/038060 A1