1: 1.) Mg / 2.) PdCl2*dppb / 1.) THF, reflux, 1 h, 2.) THF, 60 to 48 deg C, 40 min 2: 43 percent / Fe, Br2 / 1,2-dichloro-ethane / 1.) 65 deg C, 2 h, 2.) 20 deg C, 3 d 3: 1.) Mg / 2.) PdCl2*dppb / 1.) THF, reflux, 1 h, 2.) THF, reflux View Scheme

1: 43 percent / Fe, Br2 / 1,2-dichloro-ethane / 1.) 65 deg C, 2 h, 2.) 20 deg C, 3 d 2: 1.) Mg / 2.) PdCl2*dppb / 1.) THF, reflux, 1 h, 2.) THF, reflux View Scheme

1: 1.) Mg / 2.) PdCl2*dppb / 1.) THF, reflux, 1 h, 2.) THF, 60 to 48 deg C, 40 min 2: 43 percent / Fe, Br2 / 1,2-dichloro-ethane / 1.) 65 deg C, 2 h, 2.) 20 deg C, 3 d 3: 1.) Mg / 2.) PdCl2*dppb / 1.) THF, reflux, 1 h, 2.) THF, reflux View Scheme

1: various solvent(s) / 3 h / Heating 2: KOH / methanol / 24 h / Heating 3: 11.3 percent / K3Fe(CN)6, Na2CO3 / H2O / 1) heating, 20 min, 2) r.t., 2 d View Scheme

1: 54 percent / LiOEt / ethanol / 24 h / Ambient temperature 2: various solvent(s) / 3 h / Heating 3: KOH / methanol / 24 h / Heating 4: 11.3 percent / K3Fe(CN)6, Na2CO3 / H2O / 1) heating, 20 min, 2) r.t., 2 d View Scheme

magnesium; [1,4-bis-(diphenylphosphine)butane]palladium (II) dichloride 1.) THF, reflux, 1 h, 2.) THF, reflux; Yield givenMultistep reaction;