2-甲基-2-丙基甲基(4-氧代丁基)氨基甲酸酯合成路线 （共 4 条）
反应条件
4-methylmorpholine N-oxide; tetrapropylammonium perruthennate in dichloromethane T=20°C; 1 h;
参考文献
Bridger, Gary; Skerlj, Renato; Kaller, Ai; Harwig, Curtis; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher Dennis; Di Fluri, Maria Rosaria
Patent: US2003/220341 A1, 2003 ;
Location in patent: Page/Page column 32-33 ;
US 20030220341 A1
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=20°C; 1 h;
参考文献
Xiao, Xiangshu; Antony, Smitha; Kohlhagen, Glenda; Pommier, Yves; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 19 p. 5147 - 5160
反应条件
silica gel in dichloromethane
参考文献
Janssen Pharmaceutical N.V.
Patent: US4975439 A1, 1990 ;
反应条件
1: 82 percent / Et3N; BOP / CH2Cl2 / 1 h / 20 °C 2: 61 percent / LiAlH4 / tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Xiao, Xiangshu; Antony, Smitha; Kohlhagen, Glenda; Pommier, Yves; Cushman, Mark
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 19 p. 5147 - 5160
