1: 64 percent / 0.1 M HCl / 15 h / Heating 2: 91 percent / pyridine, 4-(dimethylamino)pyridine / 1.5 h / Ambient temperature 3: 67 percent / triethylamine / CH2Cl2 / 24 h / Heating 4: 99 percent / NH3 (g), CH3OH / 16 h / Ambient temperature 5: 60 percent / 1 M NBu4F / tetrahydrofuran / 18 h / Heating 6: 45 percent / SnCl4 / CH2Cl2 / 2 h View Scheme

1: 64 percent / 0.1 M HCl / 15 h / Heating 2: 45 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / dimethylformamide / 30 h / Heating 3: 74 percent / aq. M NaOH / dioxane / 6 h / Ambient temperature View Scheme

With  hydrogenchloride 15 h;  Heating;   

Multi-step reaction with 2 steps 1: 64 percent / 0.1 M HCl / 15 h / Heating2: 91 percent / pyridine, 4-(dimethylamino)pyridine / 1.5 h / Ambient temperature  

Multi-step reaction with 2 steps 1: 64 percent / 0.1 M HCl / 15 h / Heating2: 45 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / dimethylformamide / 30 h / Heating  

Multi-step reaction with 3 steps 1: 64 percent / 0.1 M HCl / 15 h / Heating2: 91 percent / pyridine, 4-(dimethylamino)pyridine / 1.5 h / Ambient temperature3: 67 percent / triethylamine / CH2Cl2 / 24 h / Heating  

Multi-step reaction with 4 steps 1: 64 percent / 0.1 M HCl / 15 h / Heating2: 91 percent / pyridine, 4-(dimethylamino)pyridine / 1.5 h / Ambient temperature3: 67 percent / triethylamine / CH2Cl2 / 24 h / Heating4: 99 percent / NH3 (g), CH3OH / 16 h / Ambient temperature  

Multi-step reaction with 5 steps 1: 64 percent / 0.1 M HCl / 15 h / Heating2: 91 percent / pyridine, 4-(dimethylamino)pyridine / 1.5 h / Ambient temperature3: 67 percent / triethylamine / CH2Cl2 / 24 h / Heating4: 99 percent / NH3 (g), CH3OH / 16 h / Ambient temperature5: 60 percent / 1 M NBu4F / tetrahydrofuran / 18 h / Heating