5-氯-2,4-二磺酰胺基苯胺合成路线 （共 45 条）
反应条件
sodium hydroxide; iodine; potassium iodide T=0 - 4°C;
参考文献
Supuran, Claudiu T; Briganti, Fabrizio; Tilli, Silvia; Chegwidden; Scozzafava, Andrea
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 703 - 714
反应条件
sodium hydroxide; sodium hypochlorite T=25 - 30°C;
参考文献
Supuran, Claudiu T; Briganti, Fabrizio; Tilli, Silvia; Chegwidden; Scozzafava, Andrea
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 3 p. 703 - 714
反应条件
hydrogenchloride in diethylene glycol dimethyl ether Heating;
参考文献
Bollettino Chimico Farmaceutico, , vol. 100, p. 956 - 971
反应条件
hydrogenchloride in ethanol 12 h; Ambient temperature;
参考文献
Whitehead,C.W. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 2814 - 2818
参考文献
USV Limited
Patent: US2011/263579 A1, 2011 ;
Location in patent: Page/Page column 9 ;
参考文献
ALEMBIC LIMITED
Patent: WO2009/150497 A1, 2009 ;
Location in patent: Page/Page column 9 ;
反应条件
hydrogenchloride in diethylene glycol dimethyl ether Heating;
参考文献
Topliss,J.G. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 3842 - 3850
反应条件
sulfuric acid Heating;
参考文献
Klosa,J.
Journal fuer Praktische Chemie (Leipzig), 1966 , vol. 33, p. 298 - 306
反应条件
(i) aq. H2O2, HCO2H, (ii) /BRN= 1083877/, aq. H2SO4; Multistep reaction;
参考文献
Klosa,J.
Journal fuer Praktische Chemie (Leipzig), 1966 , vol. 33, p. 298 - 306
反应条件
1: 1 h / 180 °C 2: NaH / dimethylformamide / 1 h / 70 °C 3: aq. NaOH / Heating 4: H2O View Scheme
参考文献
Close,W.J. et al.
Journal of the American Chemical Society, 1960 , vol. 82, p. 1132 - 1135
