5-氯-2,4-二磺酰胺基苯胺合成路线 （共 45 条）
反应条件
hydrogenchloride in ethanol 5 h; Heating;
参考文献
Klosa,J.; Voigt,H.
Journal fuer Praktische Chemie (Leipzig), 1962 , vol. 16, p. 264 - 276
反应条件
hydrogenchloride in N,N-dimethyl-formamide Heating;
参考文献
Craveri,F.; Zoni,G.
Bollettino Chimico Farmaceutico, 1961 , vol. 100, p. 956 - 971
反应条件
sodium hydroxide; sodium hypochlorite
T=25 - 30°C; thiocarbamylation;
参考文献
Scozzafava, Andrea; Supuran, Claudiu T.
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 10 p. 1117 - 1120
反应条件
in tetrahydrofuran
8 h; Heating;
参考文献
Khelili, Smail; Faury, Gilles; Nicolle, Edwige; Verdetti, Jean; Leclerc, Gerard
Medicinal Chemistry Research, 2003 , vol. 12, # 9 p. 457 - 470
反应条件
1: aq. HCl / dimethylformamide
2: AcOH / ethanol / Heating
View Scheme
参考文献
Robertson,J.E. et al.
J. Med. Chem., 1965 , vol. 8, p. 90 - 95
参考文献
E. R. Squibb and Sons, Inc.
Patent: US4536501 A1, 1985 ;
US 4536501 A
参考文献
Raffa,L. et al.
Farmaco, Edizione Scientifica, 1960 , vol. 15, p. 668 - 678
反应条件
1: H2, aq. NaOH / Pd-C
2: H2SO4
View Scheme
参考文献
Novello,F.C. et al.
Journal of Organic Chemistry, 1960 , vol. 25, p. 965 - 970
反应条件
in N,N-dimethyl-formamide
参考文献
Topliss,J.G. et al.
Journal of Organic Chemistry, 1961 , vol. 26, p. 3842 - 3850
反应条件
hydrogenchloride in ethanol
Heating;
参考文献
Klosa,J.; Voigt,H.
Journal fuer Praktische Chemie (Leipzig), 1962 , vol. 16, p. 264 - 276
