反应条件
Li(CH2)3CH3; HCl in tetrahydrofuran
(under Ar, Schlenk); soln. of ligand in THF cooled to -90°C, Li(CH2)3CH3 added, stirred for 45 min at -65°C, treated with B(OCH3)3, warmed to room temp., stirred overnight, H2O added, acidified by HCl pH 3-5; extd. with Et2O, organic layer washed with brine, H2O, dried, solvent removed, residue refluxed in H2O for 2 h, filtered, filtrate cooled to 0°C for 10 min, filtered, silica column chromy. (pentane-EtOAc 4:1),washed with pentane; elem. anal.;
参考文献
Filthaus, Matthias; Oppel, Iris M.; Bettinger, Holger F.
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 7 p. 1201 - 1207
