反应条件
1.1: hydrogen; potassium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / (R)-4-isopropyl-2-[(R)-2-(diphenylphosphino)ferrocen-1-yl]oxazoline triphenylphosphino Ru(II) dichloride / isopropyl alcohol / 22 h / 50 °C / 15001.5 Torr / Autoclave 2.1: 4-(N,N-dimethlyamino)pyridine / ethyl acetate / 0.25 h / 20 °C / Inert atmosphere 2.2: 4 h / -5 - 20 °C 3.1: ethyl acetate / 14 h / 15 - 25 °C 4.1: sodium hydroxide; water / ethyl acetate / 2 h / 90 °C 4.2: 80 °C / pH 8.7 View Scheme
参考文献
Yan, Pu-Cha; Zhu, Guo-Liang; Xie, Jian-Hua; Zhang, Xiang-Dong; Zhou, Qi-Lin; Li, Yuan-Qiang; Shen, Wen-He; Che, Da-Qing
Organic Process Research and Development, 2013 , vol. 17, # 2 p. 307 - 312