2-氨基-5-硝基苯酚合成路线 （共 116 条）
反应条件
1: 38 percent / sodium hydrogen carbonate / diethyl ether; diethyl ether; H2O / 20 °C
2: 80 percent / hydrogen / Pd/C / ethanol / 2068.59 Torr
View Scheme
参考文献
Ertan, Tugba; Yildiz, Ilkay; Ozkan, Semiha; Temiz-Arpaci, Ozlem; Kaynak, Fatma; Yalcin, Ismail; Aki-Sener, Esin; Abbasoglu, Ufuk
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 5 p. 2032 - 2044
反应条件
1: AlCl3, Py / dioxane / Heating
2: H2 / Raney-Ni / dioxane
3: NaHCO3 / dioxane; nitrobenzene
View Scheme
参考文献
Agfa Gevaert AG
Patent: DE2156480 , 1972 ;
Chem.Abstr., 1972 , vol. 77, # 141498
反应条件
1: 2-amino-5-nitro-phenol With hydrogenchloride; sodium hydroxide; sodium nitrite in water
1 h; Cooling with ice;
2: ethyl acetoacetate With sodium acetate in ethanol; water
T=0°C; Japp-Klingemann reaction; pH=8 - 10;
参考文献
Kopylovich, Maximilian N.; Mahmudov, Kamran T.; Da Silva, M. Fatima C. Guedes; Figiel, Pawel J.; Karabach, Yauhen Yu.; Kuznetsov, Maxim L.; Luzyanin, Konstantin V.; Pombeiro, Armando J.L.
Inorganic Chemistry, 2011 , vol. 50, # 3 p. 918 - 931
反应条件
1: KOH / ethanol
2: PCl5 / toluene
View Scheme
参考文献
Yamada, Megumi; Sato, Yasuo; Kobayashi, Kazuko; Konno, Fukio; Soneda, Tomoko; Watanabe, Takashi
Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 3 p. 445 - 451
反应条件
1.1: polyphosphoric acid (PPA) / 8 h / Heating
2.1: iron / ethanol / 85 °C / Heating
2.2: 80 - 85 °C
View Scheme
参考文献
Wei, Cheng-Xi; Wu, Di; Sun, Zhi-Gang; Chai, Kyu-Yun; Quan, Zhe-Shan
Medicinal Chemistry Research, 2010 , vol. 19, # 8 p. 925 - 935
反应条件
1: aq. ethanol / 0.5 h / Ambient temperature
2: Pb(OAc)4 / acetonitrile / 0.08 h / Heating
3: H2 / PtO2 / ethanol / 2585.7 Torr
View Scheme
参考文献
Haugwitz; Angel; Jacobs; Maurer; Narayanan; Cruthers; Szanto
Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 969 - 974
