2-氨基-5-硝基苯酚合成路线 （共 116 条）
反应条件
potassium carbonate in N,N-dimethyl-formamide 5 h; Heating;
参考文献
Wang, Min; Lacy, Gabrielle; Gao, Mingzhang; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 2 p. 332 - 336
反应条件
1: acetic acid / 60 °C 2: potassium carbonate / N,N-dimethyl-formamide / 60 °C 3: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C 4: toluene / 90 °C 5: dowtherm A / 250 °C 6: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C 7: pyridine hydrochloride / isopropyl alcohol / Reflux 8: hydrogenchloride / water / Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 5 p. 2251 - 2264
反应条件
1.1: boric acid / anhydrous xylene / |Reflux 2.1: palladium on activated charcoal; hydrogen / ethanol / 0.01 h / |Sonication 2.2: 68 h / 20 °C View Scheme
参考文献
Schroeder, Marcus; Kolodzik, Adrian; Pfaff, Katharina; Priyadarshini, Poornima; Krepstakies, Marcel; Hauber, Joachim; Rarey, Matthias; Meier, Chris
ChemMedChem, 2014 , vol. 9, # 5 p. 940 - 952
反应条件
1: in tetrahydrofuran T=0 - 20°C; 15 h; 2: With hydrogenchloride in water T=0 - 20°C; 3 h;
参考文献
SHIONOGI and CO., LTD.
Patent: EP1988077 A1, 2008 ;
Location in patent: Page/Page column 68 ;
参考文献
Rawson, Thomas E.; Safina, Brian; Dotson, Jennafer; Zhou, Aihe; Aliagas-Martin, Ignacio; Halladay, Jason; Liang, Jun; Rueth, Matthias; Zhu, Bing-Yan
Patent: US2007/37791 A1, 2007 ;
Location in patent: Page/Page column 51 ;
US 20070037791 A1
反应条件
1: 1.7 percent / 0.33 h / 160 °C 2: 78 percent / 1 h / 180 °C View Scheme
参考文献
Desai et al.
Journal of the Chemical Society, 1938 , p. 321,326
反应条件
in dichloromethane T=20°C; 72 h; Heating / reflux;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2007/18941 A2, 2007 ;
Location in patent: Page/Page column 48-49 ;
WO 2007/018941 A2
反应条件
1: With sulfuric acid; sodium nitrite in water; dimethyl sulfoxide T=5°C; Sandmeyer Reaction; 2: With sodium iodide in water; dimethyl sulfoxide T=5 - 20°C;
参考文献
Sanofi Aventis
Patent: US2009/318473 A1, 2009 ;
Location in patent: Page/Page column 23 ;
参考文献
Meldola; Eyre
Chem. News J. Ind. Sci., 1901 , vol. 83, p. 1076,285
参考文献
Kim, Jung Sun; Sun, Qun; Gatto, Barbara; Yu, Chiang; Liu, Angela; Liu, Leroy F.; LaVoie, Edmond J.
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 4 p. 621 - 630
