2-氨基-5-硝基苯酚合成路线 （共 116 条）
反应条件
pyridine in tetrahydrofuran
T=20°C; 4 h;
参考文献
Sun, Li-Ping; Huang, Xiang-Hong; Dai, Wei-Min
Tetrahedron, 2004 , vol. 60, # 48 p. 10983 - 10992
反应条件
1: arsenic acid; sulfuric acid; water
2: SnCl2; aqueous HCl
View Scheme
参考文献
Vogt; Jeske
Archiv der Pharmazie (Weinheim, Germany), 1958 , vol. 291, p. 168,175
反应条件
potassium fluoride in N,N-dimethyl-formamide
T=50 - 60°C; 6 h;
参考文献
Shridhar; Gandhi Rao
Synthesis, 1982 , vol. No. 11, p. 986 - 987
反应条件
1: 75 percent / methanol / 0.5 h / Heating
2: H2 / Raney nickel / ethanol
View Scheme
参考文献
Bris, Marie-Therese Le
Journal of Heterocyclic Chemistry, 1984 , vol. 21, p. 551 - 555
反应条件
T=160°C; 0.333333 h;
参考文献
Nachman
Journal of Heterocyclic Chemistry, 1983 , vol. 20, # 5 p. 1423 - 1425
反应条件
1: acetic acid / 60 °C
2: potassium carbonate / N,N-dimethyl-formamide / 60 °C
3: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
4: toluene / 90 °C
5: dowtherm A / 250 °C
6: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C
7: pyridine hydrochloride / isopropyl alcohol / Reflux
8: hydrogenchloride / water / 5 h / Reflux
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
1: acetic acid / 60 °C
2: potassium carbonate / N,N-dimethyl-formamide / 60 °C
3: 10 palladium on activated charcoal; hydrogen / tetrahydrofuran / 20 °C
4: toluene / 90 °C
5: dowtherm A / 250 °C
6: trichlorophosphate / diethylene glycol dimethyl ether / 100 °C
7: pyridine hydrochloride / isopropyl alcohol / Reflux
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
1: 96 percent / AcOH / 60 °C
2: 98 percent / K2CO3 / dimethylformamide / 60 °C
3: H2 / Pd/C / tetrahydrofuran / 3 h / 28 - 30 °C / 2585.74 Torr
View Scheme
参考文献
Carmi, Caterina; Galvani, Elena; Vacondio, Federica; Rivara, Silvia; Lodola, Alessio; Russo, Simonetta; Aiello, Stefania; Bordi, Fabrizio; Costantino, Gabriele; Cavazzoni, Andrea; Alfieri, Roberta R.; Ardizzoni, Andrea; Petronini, Pier Giorgio; Mor, Marco
Journal of Medicinal Chemistry, 2012 , vol. 55, # 5 p. 2251 - 2264
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=80°C; 12 h;
参考文献
Li, Zhong'an; Zeng, Qi; Li, Zhen; Dong, Shoucheng; Zhu, Zhichao; Li, Qianqian; Ye, Cheng; Di, Chong'an; Liu, Yunqi; Qin, Jingui
Macromolecules, 2006 , vol. 39, # 24 p. 8544 - 8546
反应条件
pyridine in N,N-dimethyl-formamide
24 h; Heating;
参考文献
Palek, Lukas; Dvorak, Jaroslav; Svobodova, Michaela; Buchta, Vladimir; Jampilek, Josef; Dolezal, Martin
Archiv der Pharmazie, 2008 , vol. 341, # 1 p. 61 - 65
