甲基4-甲氧基苯甲酸酯合成路线 （共 354 条）
参考文献
Cahours
Justus Liebigs Annalen der Chemie, 1845 , vol. 56, p. 308
Annales de Chimie (Cachan, France), 1845 , vol. <3> 14, p. 486
反应条件
1.1: CH3BF3(1-)*H(1+)*C4H10O; N-bromosuccinmide / acetonitrile / 23 h / -10 - 20 °C / |Inert atmosphere 2.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / |Inert atmosphere 3.1: oxalyl dichloride; dimethyl sulfate / dichloromethane / 1 h / -78 °C / |Inert atmosphere 3.2: 2 h / -78 - 20 °C / |Inert atmosphere View Scheme
参考文献
Ogura, Tetsuhiro; Usuki, Toyonobu
Tetrahedron, 2013 , vol. 69, # 13 p. 2807 - 2815
反应条件
hydrazine hydrate in methanol 2 h; Inert atmosphereReflux;
参考文献
Journal of the American Chemical Society, , vol. 135, # 15 p. 5656 - 5668
反应条件
Oxonereg;; potassium chloride in water; acetonitrile T=20°C;
参考文献
Tamhankar; Desai; Mane; Wadgaonkar; Bedekar
Synthetic Communications, 2001 , vol. 31, # 13 p. 2021 - 2027
反应条件
formic acid; fluorine T=10°C; Fluorination; 1.75 h;
参考文献
Chambers, Richard D.; Hutchinson, John; Sparrowhawk, Matthew E.; Sandford, Graham; Moilliet, John S.; Thomson, Julie
Journal of Fluorine Chemistry, 2000 , vol. 102, # 1-2 p. 169 - 173
反应条件
1: With sodium methylate in dimethyl sulfoxide T=110°C; 2 h; 2: With water in dimethyl sulfoxide; acetonitrile T=15°C; 3: With hydrogenchloride in water; dimethyl sulfoxide; acetonitrile T=20°C; pH=7.9;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/111046 A1, 2005 ;
Location in patent: Page/Page column 41-42 ;
反应条件
aluminium trichloride in nitromethane Friedel-Crafts conditions; other solvent: carbon disulphide;
参考文献
McKillop, Alexander; Madjdabadi, Fereidon Abbasi; Long, David A.
Tetrahedron Letters, 1983 , vol. 24, # 18 p. 1933 - 1936
反应条件
1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / |Inert atmosphere 2: thionyl chloride / diethyl ether / 3 h / 20 °C / |Inert atmosphere 3: toluene / 7 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Ogura, Tetsuhiro; Usuki, Toyonobu
Tetrahedron, 2013 , vol. 69, # 13 p. 2807 - 2815
反应条件
N-bromosuccinmide; CH3BF3(1-)*H(1+)*C4H10O in acetonitrile T=-10 - 20°C; 23 h; Inert atmosphere; regioselective reaction;
参考文献
Ogura, Tetsuhiro; Usuki, Toyonobu
Tetrahedron, 2013 , vol. 69, # 13 p. 2807 - 2815
反应条件
tetrafluoroboric acid diethyl ether complex; N-bromosuccinmide in acetonitrile 23 h; Ambient temperature; Yield given. Yields of byproduct given;
参考文献
Oberhauser, Thomas
Journal of Organic Chemistry, 1997 , vol. 62, p. 4504 - 4506
