甲基4-甲氧基苯甲酸酯合成路线 （共 354 条）
反应条件
1: 1) lithium 2,2,6,6-tetramethylpiperidide / 1) -10 degC, THF, 2) 0 degC, 20 min 2: 1) lithium 2,2,6,6-tetramethylpiperidide / 1) -10 degC, THF, 2) 0 degC, 20 min View Scheme
参考文献
Bartoli, Giuseppe; Palmieri, Gianni; Petrini, Marino
Tetrahedron, 1990 , vol. 46, # 4 p. 1379 - 1384
反应条件
1: α-tetralon oxime With lithium diisopropyl amide in tetrahydrofuran Metallation; dilithiation; 2: methyl 4-(N-tert-butoxycarbonyl-(5S)-methyl-(2S)-pyrrolidinylmethoxy)benzoate in tetrahydrofuran Condensation; 1.5 h; 3: With hydrogenchloride Cyclization; 1 h; Heating;
参考文献
Beam, Charles F.; Schady, Deborah A.; Rose, Kelly L.; Kelley Jr., Wayne; Rakkhit, Ronjay; Hornsby, Christopher D.; Studer-Martinez, Shannon L.
Synthetic Communications, 2000 , vol. 30, # 18 p. 3391 - 3404
反应条件
(i) nBuLi, THF, (ii) /BRN= 2208571/, (iii) aq. HCl; Multistep reaction;
参考文献
Beam,C.F. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 1806 - 1810
反应条件
(i) nBuLi, THF, (ii) /BRN= 2208571/, (iii) aq. HCl; Multistep reaction;
参考文献
Beam,C.F. et al.
Journal of Organic Chemistry, 1970 , vol. 35, p. 1806 - 1810
反应条件
1: 89 percent / hydrazine monohydrate / 3 h / 120 °C 2: 66 percent / 120 - 140 °C 3: 55 percent / BBr3 / CH2Cl2 / 72 h / 20 °C View Scheme
参考文献
Sadek, Bassem; Fahelelbom, Khairi Mustafa Salem
Molecules, 2011 , vol. 16, # 6 p. 4339 - 4347
反应条件
1: 94.4 percent / LiAlH4 / diethyl ether / 4 h / Heating 2: 93.8 percent / SOCl2 / diethyl ether / 3 h / 20 °C View Scheme
参考文献
Ogura, Tetsuhiro; Usuki, Toyonobu
Tetrahedron, 2013 , vol. 69, # 13 p. 2807 - 2815
反应条件
1: hydrazine hydrate / 28 h / Heating 2: p-toluenesulfonic acid monohydrate / 80 - 120 °C View Scheme
参考文献
Liu, Qiang; Wu, Pan; Yang, Yuhong; Zeng, Ziqi; Liu, Jie; Yi, Hong; Lei, Aiwen
Angewandte Chemie - International Edition, 2012 , vol. 51, # 19 p. 4666 - 4670
反应条件
1: methyl 4-(N-tert-butoxycarbonyl-(5S)-methyl-(2S)-pyrrolidinylmethoxy)benzoate With hydrazine hydrate T=20°C; 2: trimethyl orthoformate 10 h; Heating;
参考文献
Nowak-Wydra, Barbara; Gierczyk, Blazej; Schroeder, Grzegorz
Magnetic Resonance in Chemistry, 2003 , vol. 41, # 9 p. 689 - 692
反应条件
1.1: lithium diisopropylamide / tetrahydrofuran / -78 °C 1.2: tetrahydrofuran / -78 - 20 °C 2.1: hydrazine monohydrate / ethanol / 5 h / Heating View Scheme
参考文献
Takahashi, Toshiyuki; Sakuraba, Aya; Hirohashi, Tomoko; Shibata, Takunobu; Hirose, Masaaki; Haga, Yuji; Nonoshita, Katsumasa; Kanno, Tetsuya; Ito, Junko; Iwaasa, Hisashi; Kanatani, Akio; Fukami, Takehiro; Sato, Nagaaki
Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 22 p. 7501 - 7511
反应条件
1: 79 percent / NaH / tetrahydrofuran / 48 h / 60 °C 2: 80 percent / hydrazine hydrate; aq. HCl / ethanol / 9 h / Heating View Scheme
参考文献
Hudson, Sean A.; Surade, Sachin; Coyne, Anthony G.; Mclean, Kirsty J.; Leys, David; Munro, Andrew W.; Abell, Chris
ChemMedChem, 2013 , vol. 8, # 9 p. 1451 - 1456
