甲基4-甲氧基苯甲酸酯合成路线 （共 354 条）
反应条件
sulfuric acid
durch elektrolytische Reduktion;
参考文献
Baxter, Steven L.; Bradshaw, Jerald S.
Journal of Organic Chemistry, 1981 , vol. 46, # 4 p. 831 - 832
参考文献
de Oliveira Baptista; Barrett; Barton; Girijavallabhan; Jennings; Kelly; Papadimitriou; Turner; Usher
Journal of the Chemical Society. Perkin transactions 1, 1977 , # 12 p. 1477 - 1500
反应条件
1: 95 percent / hydrazine
2: 84 percent
3: 1.) PCl3 / 1.) 1,2-dichlorobenzene; 2.) reflux
View Scheme
参考文献
Clemence; Joliveau-Maushart; Meier; et al.
European Journal of Medicinal Chemistry, 1985 , vol. 20, # 3 p. 257 - 266
反应条件
1: sodium hydride / dimethyl sulfoxide / 8 °C
2: potassium tert-butylate / tetrahydrofuran / Reflux
View Scheme
参考文献
Schaefer, Anja; Wellner, Anja; Gust, Ronald
ChemMedChem, 2011 , vol. 6, # 5 p. 794 - 803
反应条件
sodium methylate in methanol
T=25°C; 3480 h; Equilibrium constant;
参考文献
Guthrie, J. Peter; Pike, David C.; Lee, Yiu-Chung
Canadian Journal of Chemistry, 1992 , vol. 70, # 6 p. 1671 - 1683
反应条件
sodium hydride in toluene
Heating;
参考文献
Sund, Eldon H.; Callender, David L.
Journal of Chemical & Engineering Data, 1980 , vol. 25, # 2 p. 189
反应条件
1: 1.) magnesium / 1.) ether, reflux, 0.5 h, 2.) ether, reflux, 2 h
2: 60 percent / TiCl3, LiAlH4 / 1,2-dimethoxy-ethane / 16 h / Heating
3: 89 percent / BBr3 / CH2Cl2 / 1.) -60 deg C, 0.5 h, 2.) RT, 4 h
View Scheme
参考文献
Hartmann, Rolf W.; Kranzfelder, Gerhard; Angerer, Erwin, v.; Schoenenberger, Helmut
Journal of Medicinal Chemistry, 1980 , vol. 23, # 8 p. 841 - 848
参考文献
Dermer; King
Journal of Organic Chemistry, 1943 , vol. 8, p. 168,171
反应条件
1: morpholine With Sm(III) chloride; lithium hexamethyldisilazane in tetrahydrofuran
T=20°C;
2: methyl 4-(N-tert-butoxycarbonyl-(5S)-methyl-(2S)-pyrrolidinylmethoxy)benzoate in tetrahydrofuran
T=0°C;
参考文献
Campbell, James B.; Sparks, Richard B.; Dedinas, Robert F.
Synlett, 2011 , # 3 art. no. S08010ST, p. 357 - 360
反应条件
1: 94.4 percent / LiAlH4 / diethyl ether / 4 h / Heating
2: 93.8 percent / SOCl2 / diethyl ether / 3 h / 20 °C
3: 4 h / Heating
4: NaOEt / dimethylformamide; ethanol / 3 h / 20 °C
5: BBr3 / CH2Cl2 / -10 - 0 °C
View Scheme
参考文献
Chen, Guoliang; Shan, Wei; Wu, Yingliang; Ren, Lixiang; Dong, Jinhua; Ji, Zhizhong
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 12 p. 1587 - 1590
