甲基4-甲氧基苯甲酸酯合成路线 （共 354 条）
反应条件
1: 1.) sec-BuLi
2: 99 percent / NaBH4 / ethanol / 2 h
3: 82 percent / p-Toluenesulfonic acid / toluene / 8 h / Heating
View Scheme
参考文献
Watanabe, Mitsuaki; Sahara, Masanori; Kubo, Masaki; Furukawa, Sunao; Billedeau, R. J.; Snieckus, V.
Journal of Organic Chemistry, 1984 , vol. 49, # 5 p. 742 - 747
反应条件
1: 85 percent / KSCOCH3; Triton X-405 / 150 °C
2: 70 °C
View Scheme
参考文献
Bhattacharya, Apurba; Patel, Nitin C.; Vasques, Tomas; Tichkule, Ritesh; Parmar, Gaurang; Wu, Jiejun
Tetrahedron Letters, 2006 , vol. 47, # 4 p. 565 - 567
反应条件
Co2(μ2-OCH2C6H4-4-CH3)2(η2-OCOtBu)2(2,2’-bipyridine)2; 4-methyl benzyl amine in toluene
18 h; RefluxInert atmosphereSchlenk technique; chemoselective reaction;
参考文献
Hayashi, Yukiko; Santoro, Stefano; Azuma, Yuki; Himo, Fahmi; Ohshima, Takashi; Mashima, Kazushi
Journal of the American Chemical Society, 2013 , vol. 135, # 16 p. 6192 - 6199
反应条件
n-butyllithium in diethyl ether; hexane
T=0°C; 2 h;
参考文献
Deka, Dibakar C.; Purkayastha, Biswajit; Paul, Maumita
Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 2003 , vol. 42, # 10 p. 2641 - 2642
反应条件
n-butyllithium; diisopropylamine in diethyl ether; hexane
1.) 0 deg C, 20 min., 2.) 0 deg C, 3 h;
参考文献
Aoyama, Toyohiko; Shioiri, Takayuki
Chemical & Pharmaceutical Bulletin, 1982 , vol. 30, # 9 p. 3450 - 3453
反应条件
1: hydrazine
2: pyridine / Heating
3: trichlorophosphate / 10 h / Reflux
View Scheme
参考文献
Gierczyk, Blazej; Zalas, MacIej; Kazmierczak, Marcin; Grajewski, Jakub; Pankiewicz, Radoslaw; Wyrzykiewicz, Bozena
Magnetic Resonance in Chemistry, 2011 , vol. 49, # 10 p. 648 - 654
反应条件
1.1: CH3BF3(1-)*H(1+)*C4H10O; N-bromosuccinmide / acetonitrile / 23 h / -10 - 20 °C / |Inert atmosphere
2.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / -78 - 0 °C / |Inert atmosphere
3.1: triphenylphosphine / dichloromethane / 0.17 h / 20 °C / |Inert atmosphere
3.2: 2 h / -78 °C / |Inert atmosphere
View Scheme
参考文献
Ogura, Tetsuhiro; Usuki, Toyonobu
Tetrahedron, 2013 , vol. 69, # 13 p. 2807 - 2815
反应条件
hydrogenchloride in water; ethyl acetate; toluene
参考文献
Haarmann and Reimer GmbH
Patent: US4562067 A1, 1985 ;
反应条件
1: 94.4 percent / LiAlH4 / diethyl ether / 4 h / Heating
2: 93.8 percent / SOCl2 / diethyl ether / 3 h / 20 °C
3: 4 h / Heating
4: NaOEt / dimethylformamide; ethanol / 3 h / 20 °C
View Scheme
参考文献
Chen, Guoliang; Shan, Wei; Wu, Yingliang; Ren, Lixiang; Dong, Jinhua; Ji, Zhizhong
Chemical and Pharmaceutical Bulletin, 2005 , vol. 53, # 12 p. 1587 - 1590
反应条件
triphenylmethyllithium in tetrahydrofuran
T=-15°C;
参考文献
Griffin, David A.; Leeper, Finian J.; Staunton, James
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 5 p. 1035 - 1042
