6-甲氧基-1-甲基-2,3,4,9-四氢-1H-吡啶并[3,4-b]吲哚合成路线 （共 6 条）
反应条件
in water 24 h; Ambient temperaturepH=4.1 (phosphate buffer);
参考文献
Sapi, Janos; Patigny, Dominique; Laronze, Jean-Yves
Heterocycles, 1999 , vol. 51, # 2 p. 361 - 364
反应条件
hydrogenchloride in methanol T=20°C; Pictet-Spengler cyclisation;
参考文献
Cuny, Gregory D.; Ulyanova, Natalia P.; Patnaik, Debasis; Liu, Ji-Feng; Lin, Xiangjie; Auerbach, Ken; Ray, Soumya S.; Xian, Jun; Glicksman, Marcie A.; Stein, Ross L.; Higgins, Jonathan M.G.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 5 p. 2015 - 2019
反应条件
hydrogenchloride T=100°C;
参考文献
Schott, Yvonne; Decker, Michael; Rommelspacher, Hans; Lehmann, Jochen
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5840 - 5843
反应条件
1: methanol; water / 12 h / 20 °C 2: HCl / 100 °C View Scheme
参考文献
Schott, Yvonne; Decker, Michael; Rommelspacher, Hans; Lehmann, Jochen
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5840 - 5843
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in toluene 3 h; Heating;
参考文献
Sapi, Janos; Patigny, Dominique; Laronze, Jean-Yves
Heterocycles, 1999 , vol. 51, # 2 p. 361 - 364
反应条件
1: cumene / Pd/C / Heating
2: HBr; CH3COOH / 130 °C
View Scheme
参考文献
Schott, Yvonne; Decker, Michael; Rommelspacher, Hans; Lehmann, Jochen
Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 22 p. 5840 - 5843
