1: 1.) m-CPBA, 2.) NH4Cl, H2O / 1.) CH2Cl2, 0 deg C 2: 72 percent / 0.1 M phosphate buffer / Baker's yeast, pH 7.0 View Scheme

Multi-step reaction with 7 steps 1: 1.) MeOTf, 2.) L-Selectride / 1,) CH2Cl2, RT, 2.) THF, -78 deg C2: 5A molecular sieves3: Heating4: 82 percent / KOH / methanol5: 93 percent / DMSO, (COCl)2 / CH2Cl2 / -60 °C6: 92 percent / 1,2-dimethoxy-ethane / 0 °C7: (S)-BINAL-H / tetrahydrofuran / -100 - -78 °C