N-(1-((2r,3r,4r,5r)-5-((双(4-甲氧基苯基)(苯基)甲氧基)甲基)-3-((叔丁基二甲基甲硅烷基)氧基)-4-羟基四氢呋喃-2-基)-2-氧代-1,2-二氢嘧啶-4-基)乙酰胺合成路线 （共 19 条）
反应条件
1: 4,4'-dimethoxytriphenylmethyl chloride; N4-acetylcytidine With pyridine T=20°C; Cooling with ice; 2: tert-butyldimethylsilyl chloride With silver nitrate in tetrahydrofuran T=20°C; Cooling with ice;
参考文献
WO2010/108140 A1, ;
Page/Page column 138-139 ;
反应条件
pyridine; silver nitrate in tetrahydrofuran T=25°C;
参考文献
Tetrahedron Letters, , vol. 39, # 14 p. 1897 - 1900
参考文献
Nucleosides, nucleotides and nucleic acids, , vol. 22, # 5-8 p. 1007 - 1009
反应条件
1.1: trifluoromethanesulfonic acid / dimethylformamide / 0.75 h / 0 °C 2.1: imidazole / dimethylformamide / 1 h / 0 - 25 °C 2.2: 87 percent / 2 h / 60 °C 3.1: CH2Cl2; pyridine / 3 h / 0 - 20 °C 3.2: methylamine / CH2Cl2; pyridine; methanol / 0.5 h 4.1: hydrogen fluoride*pyridine / pyridine; CH2Cl2 / 2 h / 0 °C 5.1: pyridine / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 11 p. 1983 - 1985
反应条件
1: 61 percent / pyridine / 25 °C 2: 57 percent / AgNO3, pyridine / tetrahydrofuran / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 14 p. 1897 - 1900
反应条件
1: 61 percent / pyridine / 25 °C 2: 57 percent / AgNO3, pyridine / tetrahydrofuran / 25 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 14 p. 1897 - 1900
反应条件
1: HF; pyridine / CH2Cl2 / 0 °C 2: 90 percent / pyridine / 0 °C View Scheme
参考文献
Nucleosides, nucleotides and nucleic acids, , vol. 22, # 5-8 p. 1007 - 1009
参考文献
Tetrahedron Letters, , vol. 36, # 49 p. 8929 - 8932
反应条件
triethylamine in methanol
参考文献
Tetrahedron Letters, , vol. 39, # 14 p. 1897 - 1900
反应条件
1.1: imidazole / dimethylformamide / 1 h / 0 - 25 °C 1.2: 87 percent / 2 h / 60 °C 2.1: CH2Cl2; pyridine / 3 h / 0 - 20 °C 2.2: methylamine / CH2Cl2; pyridine; methanol / 0.5 h 3.1: hydrogen fluoride*pyridine / pyridine; CH2Cl2 / 2 h / 0 °C 4.1: pyridine / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 43, # 11 p. 1983 - 1985
