反应条件
1: 1.) N-isopropylcyclohexylamine, 1.55 M n-butyllitium / 1.) THF, -78 deg C, 10 min., 2.) -78 deg C, 15 min 2: 1.) P2I4, 2.) KF / 1.) CH2Cl2, room temp., 10 min., 2.) methanol, room temp., 3 h 3: 1.) sodium hydride / 1.) glyme, 0 deg C, 25 min, 2a.) 0 deg C, 3h, 2b.) room temp., 12 h 4: 45 percent / W-2 Raney nickel / acetone / 3 h / Ambient temperature View Scheme
参考文献
Journal of Organic Chemistry, , vol. 50, # 14 p. 2589 - 2591
