[(1S,6S,7S,8R,8aR)-1,7,8-三羟基-1,2,3,5,6,7,8,8a-八氢吲嗪-6-基] 丁酸酯合成路线 （共 3 条）
→
121104-96-9[(1S,6S,7S,8R,8aR)-1,7,8-三羟基-1,2,3,5,6,7,8,8a-八氢吲嗪-6-基] 丁酸酯
反应条件
1: 70 percent / pyridine / 72 h / 0 deg C to r.t.
2: 82 percent / pTsOH*H2O / 1,2-dimethoxy-ethane / 55 °C
3: 92 percent / NaOMe / methanol / Ambient temperature
4: 94 percent / tetrahydrofuran / or CH2Cl2
5: 90 percent / HCl / ethanol
View Scheme
参考文献
Liu; Hoekstra; King
Tetrahedron Letters, 1990 , vol. 31, # 20 p. 2829 - 2832
→
121104-96-9[(1S,6S,7S,8R,8aR)-1,7,8-三羟基-1,2,3,5,6,7,8,8a-八氢吲嗪-6-基] 丁酸酯
反应条件
in pyridine
T=45°C; 96 h; porcine pancreatic lipase (EC 3.1.1.3);
参考文献
Margolin; Delinck; Whalon
Journal of the American Chemical Society, 1990 , vol. 112, # 8 p. 2849 - 2854
→
121104-96-9[(1S,6S,7S,8R,8aR)-1,7,8-三羟基-1,2,3,5,6,7,8,8a-八氢吲嗪-6-基] 丁酸酯
反应条件
di(n-butyl)tin oxide; triethylamine
1) MeOH, reflux, 45 min 2) room temperature, 2 h; Yield given. Multistep reaction;
参考文献
Anderson, Wayne K.; Coburn, Robert A.; Gopalsamy, Ariamala; Howe, Trevor J.
Tetrahedron Letters, 1990 , vol. 31, # 2 p. 169 - 170
