1: With n-butyllithium in tetrahydrofuran; hexane T=-75°C; 2 h; Large scale reaction; 2: With tri-isopropoxy-borane in tetrahydrofuran; hexane T=-75 - -10°C; 3 h; Enzymatic reaction; 3: With sulfuric acid; water in tetrahydrofuran; hexane T=40°C; 4 h; Enzymatic reaction;

1.1: sodium carbonate; sodium iodide / ethanol; water / 3 h / 22 °C / Inert atmosphere; Reflux; Large scale reaction 1.2: Inert atmosphere 2.1: sulfuric acid / cyclohexane / 77 - 83 °C / Inert atmosphere; Large scale reaction 3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C / Large scale reaction 3.2: 3 h / -75 - -10 °C / Enzymatic reaction 3.3: 4 h / 40 °C / Enzymatic reaction View Scheme

1.1: sodium carbonate; sodium iodide / ethanol; water / 3 h / 22 °C / Inert atmosphere; Reflux; Large scale reaction 1.2: Inert atmosphere 2.1: sulfuric acid / cyclohexane / 77 - 83 °C / Inert atmosphere; Large scale reaction 3.1: n-butyllithium / tetrahydrofuran; hexane / 2 h / -75 °C / Large scale reaction 3.2: 3 h / -75 - -10 °C / Enzymatic reaction 3.3: 4 h / 40 °C / Enzymatic reaction View Scheme