(2S,4R)-4-叠氮基-1,2-吡咯烷二甲酸1-(1,1-二甲基乙基)2-甲酯合成路线 （共 18 条）
反应条件
1: 53.4 g / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 2: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 3: 88.7 percent / dimethylsulfoxide / 90 °C 4: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C 5: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 6: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C View Scheme
参考文献
Marusawa, Hiroshi; Setoi, Hiroyuki; Sawada, Akihiko; Kuroda, Akio; Seki, Jiro; Motoyama, Yukio; Tanaka, Hirokazu
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 5 p. 1399 - 1415
反应条件
1: 88.7 percent / dimethylsulfoxide / 90 °C 2: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C 3: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 4: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C View Scheme
参考文献
Marusawa, Hiroshi; Setoi, Hiroyuki; Sawada, Akihiko; Kuroda, Akio; Seki, Jiro; Motoyama, Yukio; Tanaka, Hirokazu
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 5 p. 1399 - 1415
反应条件
1: 98.4 percent / potassium carbonate / methanol / 1 h / 20 °C 2: 100 percent / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 3: 90.8 percent / sodium azide / dimethylsulfoxide / 90 °C View Scheme
参考文献
Marusawa, Hiroshi; Setoi, Hiroyuki; Sawada, Akihiko; Kuroda, Akio; Seki, Jiro; Motoyama, Yukio; Tanaka, Hirokazu
Bioorganic and Medicinal Chemistry, 2002 , vol. 10, # 5 p. 1399 - 1415
反应条件
1.1: sodium tetrahydroborate / methanol; water / 0.42 h / 0 - 4 °C 1.2: pH 3 2.1: methanol; diethyl ether 3.1: triethylamine / dichloromethane / 0.5 h / 0 °C 4.1: sodium azide / N,N-dimethyl-formamide / 55 °C View Scheme
参考文献
Torino, Domenica; Mollica, Adriano; Pinnen, Francesco; Feliciani, Federica; Spisani, Susanna; Lucente, Gino
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 251 - 259
反应条件
1: methanol; diethyl ether 2: triethylamine / dichloromethane / 0.5 h / 0 °C 3: sodium azide / N,N-dimethyl-formamide / 55 °C View Scheme
参考文献
Torino, Domenica; Mollica, Adriano; Pinnen, Francesco; Feliciani, Federica; Spisani, Susanna; Lucente, Gino
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 251 - 259
反应条件
1: triethylamine / dichloromethane / 20 °C / Inert atmosphere 2: carbon tetrabromide; triphenylphosphine / dichloromethane / 20 °C / Inert atmosphere 3: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere View Scheme
参考文献
Lin, Chun-Yu; Yang, Ya-Ting; Ong, Chi Wi
Journal of the Chinese Chemical Society, 2012 , vol. 59, # 3 p. 436 - 442
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0°C; 1 h;
参考文献
Aebi, Johannes; Binggeli, Alfred; Green, Luke; Hartmann, Guido; Maerki, Hans P.; Mattei, Patrizio; Ricklin, Fabienne; Roche, Olivier
Patent: US2009/48238 A1, 2009 ;
Location in patent: Page/Page column 20 ;
US 20090048238 A1
反应条件
10 palladium on activated carbon; hydrogen in methanol T=20°C; P=760.051 Torr; 6 h;
参考文献
Torino, Domenica; Mollica, Adriano; Pinnen, Francesco; Feliciani, Federica; Spisani, Susanna; Lucente, Gino
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 1 p. 251 - 259
