(2S,4S)-1-叔丁基 2-甲基 4-氨基吡咯烷-1,2-二甲酸酯合成路线 （共 11 条）
反应条件
hydrogen; palladium on activated charcoal in 1,4-dioxane 24 h;
参考文献
LG LIFE SCIENCES LTD.
Patent: WO2010/56022 A2, 2010 ;
Location in patent: Page/Page column 22 ;
WO 2010/056022 A2
反应条件
1: Et3N 2: NaN3 3: H2 / Pd/BaSO4 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2441 - 2445
反应条件
1: NaN3 2: H2 / Pd/BaSO4 View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 10 p. 2441 - 2445
反应条件
1: 53.4 g / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 2: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 3: 100 percent / sodium azide / dimethylsulfoxide / 90 °C 4: H2 / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 5 p. 1399 - 1415
反应条件
1: 53.4 g / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 2: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 3: 100 percent / sodium azide / dimethylsulfoxide / 90 °C 4: H2 / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 5 p. 1399 - 1415
反应条件
1: thionyl chloride / 6 h / Heating 2: 53.4 g / triethylamine / CH2Cl2 / 4 h / 0 - 5 °C 3: 56.2 g / triethylamine / CH2Cl2 / 3 h / 0 - 5 °C 4: 100 percent / sodium azide / dimethylsulfoxide / 90 °C 5: H2 / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 10, # 5 p. 1399 - 1415
反应条件
1: NaN3 / dimethylformamide / 5 h / 50 °C 2: H2 / Pd/C / methanol / 4 h / 1551.4 Torr View Scheme
参考文献
Tetrahedron, , vol. 52, # 47 p. 15017 - 15030
参考文献
US5338755 A1, ;
US 5338755 A
反应条件
1: methanol; diethyl ether 2: triethylamine / dichloromethane / 3 h / 0 °C 3: sodium azide / N,N-dimethyl-formamide / 55 °C 4: 10 palladium on activated carbon; hydrogen / methanol / 6 h / 20 °C / 760.05 Torr View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 17, # 1 p. 251 - 259
反应条件
1: triethylamine / dichloromethane / 20 °C / Inert atmosphere 2: triethylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere 3: sodium azide / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere 4: 5 Pd(II)/C(eggshell); hydrogen / methanol View Scheme
参考文献
Journal of the Chinese Chemical Society, , vol. 59, # 3 p. 436 - 442
