3-溴-4-甲基-5-氟吡啶合成路线 (共 1 条)
反应条件
1: 3-bromo-5-fluoro-pyridine With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; 0.666667 h; 2: methyl iodide in tetrahydrofuran; n-heptane; ethylbenzene T=-78 - 20°C; 1.58333 h; 3: With ammonium chloride in tetrahydrofuran; n-heptane; ethylbenzene
参考文献
Hoffmann-La Roche Inc.; Alam, Muzaffar; DuBois, Daisy Joe; Hawley, Ronald Charles; Kennedy-Smith, Joshua; Minatti, Ana Elena; Palmer, Wylie Solang; Silva, Tania; Thakkar, Kshitij Chhabilbhai; Wilhelm, Robert Stephen
Patent: US2013/109720 A1, 2013 ;
Location in patent: Paragraph 0092; 0093 ;