4-溴-1H-吲哚-7-羧酸合成路线 （共 3 条）
反应条件
1: 4,7-Dibromo-1H-indole With tert.-butyl lithium in tetrahydrofuran; hexane T=-78 - 5°C; 2 h; 2: carbon dioxide in tetrahydrofuran; hexane T=-78 - 20°C; 1.25 h; 3: With hydrogenchloride in tetrahydrofuran; hexane; water; ethyl acetate
参考文献
BRISTOL-MYERS SQUIBB COMPANY; LIU, Chunjian; LIN, James; DELUCCA, George V.; BATT, Douglas G.; LIU, Qingjie
Patent: WO2011/159857 A1, 2011 ;
Location in patent: Page/Page column 200-201 ;
WO 2011/159857 A1
反应条件
1.1: tetrahydrofuran / 1.5 h / -40 °C 1.2: 1 h / 20 °C 2.1: tert.-butyl lithium / hexane; tetrahydrofuran / 2 h / -78 - 5 °C 2.2: 1.25 h / -78 - 20 °C View Scheme
参考文献
BRISTOL-MYERS SQUIBB COMPANY; LIU, Chunjian; LIN, James; DELUCCA, George V.; BATT, Douglas G.; LIU, Qingjie
Patent: WO2011/159857 A1, 2011 ;
WO 2011/159857 A1
反应条件
1: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in tetrahydrofuran; dichloromethane T=20°C; 1 h; 2: With ammonia in tetrahydrofuran; dichloromethane T=20°C; 4.25 h; 3: With ammonium hydroxide in tetrahydrofuran; dichloromethane; water T=20°C; 20 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; LIU, Chunjian; LIN, James; DELUCCA, George V.; BATT, Douglas G.; LIU, Qingjie
Patent: WO2011/159857 A1, 2011 ;
Location in patent: Page/Page column 201 ;
WO 2011/159857 A1
