2-氰基-3-(三氟甲基)苯甲酸甲酯合成路线 （共 3 条）
反应条件
in dimethyl sulfoxide T=60°C; 3 h;
参考文献
GLAXOSMITHKLINE LLC; KEENAN, Richard, M.; MILLER, Aaron, Bayne; QIN, Donghui
Patent: WO2013/177349 A2, 2013 ;
Location in patent: Page/Page column 40 ;
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran / 1 h / -78 °C / |Inert atmosphere 1.2: 1.83 h / -78 °C 2.1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 20 °C / |Reflux 3.1: dimethyl sulfoxide / 3 h / 60 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; KEENAN, Richard, M.; MILLER, Aaron, Bayne; QIN, Donghui
Patent: WO2013/177349 A2, 2013 ;
反应条件
1: thionyl chloride / N,N-dimethyl-formamide / 2 h / 20 °C / |Reflux 2: dimethyl sulfoxide / 3 h / 60 °C View Scheme
参考文献
GLAXOSMITHKLINE LLC; KEENAN, Richard, M.; MILLER, Aaron, Bayne; QIN, Donghui
Patent: WO2013/177349 A2, 2013 ;
