(R)-(+)-1,1,1-三氟-2-辛醇合成路线 (共 11 条)
反应条件
hydrogen; [Rh((S)-Cy,Cy-oxoProNOP)OCOCF3]2 in toluene T=30°C; P=15201 Torr; 20 h;
参考文献
Kuroki, Yoshichika; Sakamaki, Yuko; Iseki, Katsuhiko
Organic Letters, 2001 , vol. 3, # 3 p. 457 - 459
反应条件
B-chloro-diisopinocampheylborane in diethyl ether T=-25°C; 8 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Sterk, Damjan; Stephan, Michel; Mohar, Barbara
Organic Letters, 2006 , vol. 8, # 26 p. 5935 - 5938
反应条件
vinyl acetate in hexane; water T=50°C; Resolution of racemateEnzymatic reaction; Reagent/catalystSolventTemperature; enantioselective reaction;
参考文献
Wu, Zhuofu; Li, Wenzhao; Wang, Zhi; Qin, Ling; Liu, Yunling; Huo, Qisheng; Li, Zhengqiang
RSC Advances, 2014 , vol. 4, # 12 p. 6103 - 6109
反应条件
copper(l) iodide in tetrahydrofuran; diethyl ether 1.) -20 to 25 deg C, 2.) 25 deg C, 3 h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Ramachandran, P. Veeraraghavan; Gong, Baoqing; Brown, Herbert C.
Journal of Organic Chemistry, 1995 , vol. 60, # 1 p. 41 - 46
反应条件
1: 78 percent / diethyl ether; hexane / 1.5 h / -78 °C 2: (-)-diisopinocampheylchloroborane / diethyl ether / 8 h / -25 °C View Scheme
参考文献
Ramachandran, P. Veeraraghavan; Teodorovic, Aleksandar V.; Gong, Baoqing; Brown, Herbert C.
Tetrahedron: Asymmetry, 1994 , vol. 5, # 6 p. 1075 - 1086
反应条件
1: pyridine / diethyl ether; benzene 2: water; Candida rugosa lipase / 12 h / 38 °C / pH 7.28 / aq. phosphate buffer; Enzymatic reaction View Scheme
参考文献
Pozhidaev; Torgova; Molkin; Minchenko; Vashchenko; Krivoshey; Strigazzi
Molecular Crystals and Liquid Crystals, 2009 , vol. 509, # 1 p. 300 - 308
反应条件
in diethyl ether 1.) -70 deg C, 1.5 h, 2.) r.t., overnight;
参考文献
Xiao, Ling; Yamazaki, Takashi; Kitazume, Tomoya; Yonezawa, Tetsuo; Sakamoto, Yoshitake; Nogawa, Kouji
Journal of Fluorine Chemistry, 1997 , vol. 84, # 1 p. 19 - 23
反应条件
thionyl chloride; triethylamine in tetrahydrofuran; water; toluene
参考文献
IDEMITSU KOSAN COMPANY LIMITED
Patent: EP355772 A3, 1991 ;
参考文献
IDEMITSU KOSAN COMPANY LIMITED
Patent: EP355772 A3, 1991 ;
反应条件
2-(N,N-dimethylamino)-pyridine; triethylamine in dichloromethane; water