5-碘-2,4-二甲氧基苯甲醛合成路线 （共 5 条）
反应条件
iodine cloride in methanol T=20°C; 3 h;
参考文献
Meng, Charles Q.; Ni, Liming; Worsencroft, Kimberly J.; Ye, Zhihong; Weingarten, M. David; Simpson, Jacob E.; Skudlarek, Jason W.; Marino, Elaine M.; Suen, Ki-Ling; Kunsch, Charles; Souder, Amy; Howard, Randy B.; Sundell, Cynthia L.; Wasserman, Martin A.; Sikorski, James A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 6 p. 1304 - 1315
反应条件
iodine; acetic acid; periodic acid; sulfuric acid in water Heating;
参考文献
Hathaway, Bruce A.; White, Kristen L.; McGill, Mark E.
Synthetic Communications, 2007 , vol. 37, # 21 p. 3855 - 3860
反应条件
1: aq. Na2CO3 / Pd(OAc)2 / 6 h / 100 °C 2: 83 percent / water / p-toluenesulfonic acid / acetone / 20 °C 3: 87.5 percent / ICl / methanol / 3 h / 20 °C View Scheme
参考文献
Meng, Charles Q.; Ni, Liming; Worsencroft, Kimberly J.; Ye, Zhihong; Weingarten, M. David; Simpson, Jacob E.; Skudlarek, Jason W.; Marino, Elaine M.; Suen, Ki-Ling; Kunsch, Charles; Souder, Amy; Howard, Randy B.; Sundell, Cynthia L.; Wasserman, Martin A.; Sikorski, James A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 6 p. 1304 - 1315
反应条件
1: 83 percent / water / p-toluenesulfonic acid / acetone / 20 °C 2: 87.5 percent / ICl / methanol / 3 h / 20 °C View Scheme
参考文献
Meng, Charles Q.; Ni, Liming; Worsencroft, Kimberly J.; Ye, Zhihong; Weingarten, M. David; Simpson, Jacob E.; Skudlarek, Jason W.; Marino, Elaine M.; Suen, Ki-Ling; Kunsch, Charles; Souder, Amy; Howard, Randy B.; Sundell, Cynthia L.; Wasserman, Martin A.; Sikorski, James A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 6 p. 1304 - 1315
反应条件
1: 92 percent / p-toluenesulfonic acid / benzene / 6 h / Heating 2: aq. Na2CO3 / Pd(OAc)2 / 6 h / 100 °C 3: 83 percent / water / p-toluenesulfonic acid / acetone / 20 °C 4: 87.5 percent / ICl / methanol / 3 h / 20 °C View Scheme
参考文献
Meng, Charles Q.; Ni, Liming; Worsencroft, Kimberly J.; Ye, Zhihong; Weingarten, M. David; Simpson, Jacob E.; Skudlarek, Jason W.; Marino, Elaine M.; Suen, Ki-Ling; Kunsch, Charles; Souder, Amy; Howard, Randy B.; Sundell, Cynthia L.; Wasserman, Martin A.; Sikorski, James A.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 6 p. 1304 - 1315
