4-(2-苯基乙基)苯甲醛合成路线 （共 14 条）
反应条件
hydrogen; palladium in methanol P=3800 Torr; 24 h;
参考文献
Ikawa, Takashi; Sajiki, Hironao; Hirota, Kosaku
Tetrahedron, 2005 , vol. 61, # 8 p. 2217 - 2231
反应条件
hydrogen fluoride; boron trifluoride in n-heptane T=-30°C; P=15001.5 Torr; 1 h; Autoclave; Reagent/catalystTimeTemperature;
参考文献
Mitsubishi Gas Chemical Company, Inc.; KITAMURA, Mitsuharu
Patent: EP2692717 A1, 2014 ;
Location in patent: Paragraph 0050 ;
反应条件
1: With sodium acetate in N,N-dimethyl acetamide T=100°C; Heck reaction; Inert atmosphere; 2: With hydrogen in N,N-dimethyl acetamide T=20°C; P=760.051 Torr;
参考文献
Kantam, M. Lakshmi; Chakravarti, Rajashree; Chintareddy, Venkat Reddy; Sreedhar; Bhargava, Suresh
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 16 p. 2544 - 2550
反应条件
1: With tetrabutylammomium bromide; sodium acetate in N,N-dimethyl acetamide T=100°C; Heck reaction; Inert atmosphere; 2: With hydrogen in N,N-dimethyl acetamide T=20°C; P=760.051 Torr;
参考文献
Kantam, M. Lakshmi; Chakravarti, Rajashree; Chintareddy, Venkat Reddy; Sreedhar; Bhargava, Suresh
Advanced Synthesis and Catalysis, 2008 , vol. 350, # 16 p. 2544 - 2550
反应条件
tetrabutyl ammonium fluoride; tetrakis(triphenylphosphine) palladium(0) in tetrahydrofuran T=100°C; 24 h;
参考文献
Matsuhashi, Hayao; Kuroboshi, Manabu; Hatanaka, Yasuo; Hiyama, Tamejiro
Tetrahedron Letters, 1994 , vol. 35, # 35 p. 6507 - 6510
反应条件
1: (2-iodoethyl)-benzene With indium; copper(l) chloride in tetrahydrofuran T=20°C; 24 h; 2: 4-bromo-benzaldehyde With bis-triphenylphosphine-palladium(II) chloride; lithium chloride in N,N-dimethyl acetamide T=100°C; 24 h;
参考文献
Shen, Zhi-Liang; Goh, Kelvin Kau Kiat; Yang, Yong-Sheng; Lai, Yin-Chang; Wong, Colin Hong An; Cheong, Hao-Lun; Loh, Teck-Peng
Angewandte Chemie - International Edition, 2011 , vol. 50, # 2 p. 511 - 514
反应条件
1: (2-iodoethyl)-benzene With indium; copper(l) chloride in tetrahydrofuran T=20°C; 24 h; 2: 4-chlorobenzaldehyde With bis-triphenylphosphine-palladium(II) chloride; lithium chloride in N,N-dimethyl acetamide T=100°C; 24 h;
参考文献
Shen, Zhi-Liang; Goh, Kelvin Kau Kiat; Yang, Yong-Sheng; Lai, Yin-Chang; Wong, Colin Hong An; Cheong, Hao-Lun; Loh, Teck-Peng
Angewandte Chemie - International Edition, 2011 , vol. 50, # 2 p. 511 - 514
反应条件
1: 1-bromo-4-(2-phenylethyl)benzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 20°C; 16 h; Inert atmosphere;
参考文献
Scherer, Alexander; Hampel, Frank; Gray, Murray R.; Stryker, Jeffrey M.; Tykwinski, Rik R.
Journal of Physical Organic Chemistry, 2012 , vol. 25, # 7 p. 597 - 606
反应条件
2-Nitropropane; sodium ethanolate in ethanol Heating;
参考文献
Cavallini,G. et al.
Journal of Medicinal and Pharmaceutical Chemistry, 1961 , vol. 4, p. 177 - 182
反应条件
1.1: lithium hydroxide hydrate / isopropyl alcohol / 0.33 h 1.2: 16 h / Reflux 2.1: palladium 10 on activated carbon; hydrogen / toluene / 48 h / 62059.4 Torr / Autoclave 3.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 3.2: 16 h / -78 - 20 °C / Inert atmosphere View Scheme
参考文献
Scherer, Alexander; Hampel, Frank; Gray, Murray R.; Stryker, Jeffrey M.; Tykwinski, Rik R.
Journal of Physical Organic Chemistry, 2012 , vol. 25, # 7 p. 597 - 606
