(S)-2-氨基-7-甲氧基四氢萘合成路线 （共 8 条）
反应条件
1: 80 percent / amberlyst 15 / toluene / 20 h / Heating 2: 100 percent Turnov. / H2 Ru<(R)-MeO-BIPHEMP>Br2 / methanol; CH2Cl2 / 64 h / 20 °C / 37503 Torr 3: 90 percent / MeSO3H, AcOH / 24 h / 160 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 24 p. 4551 - 4554
反应条件
methanesulfonic acid; acetic acid T=160°C; 24 h;
参考文献
Devocelle, Marc; Mortreux, Andre; Agbossou, Francine; Dormoy, Jean-Robert
Tetrahedron Letters, 1999 , vol. 40, # 24 p. 4551 - 4554
参考文献
European Journal of Medicinal Chemistry, , vol. 29, # 4 p. 259 - 268
反应条件
1: 100 percent Turnov. / H2 Ru<(R)-MeO-BIPHEMP>Br2 / methanol; CH2Cl2 / 64 h / 20 °C / 37503 Torr 2: 90 percent / MeSO3H, AcOH / 24 h / 160 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 24 p. 4551 - 4554
反应条件
sodium hydroxide in water; ethyl acetate
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 6 p. 1836 - 1846
反应条件
1: sodium hydroxide / water; ethyl acetate 2: methanol; water; isopropyl alcohol; toluene / 0.5 h / Reflux 3: sodium hydroxide / water; ethyl acetate View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 6 p. 1836 - 1846
反应条件
1: Pearlman's catalist; hydrogen; acetic acid / ethanol / 24.08 h / 20 °C 2: sodium hydroxide / water; ethyl acetate 3: methanol; water; isopropyl alcohol; toluene / 0.5 h / Reflux 4: sodium hydroxide / water; ethyl acetate View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 54, # 6 p. 1836 - 1846
反应条件
ammonium hydroxide; hydrogen bromide 3 h; Heating;
参考文献
Cecchi, R.; Croci, T.; Boigegrain, R.; Boveri, S.; Baroni, M.; et al.
European Journal of Medicinal Chemistry, 1994 , vol. 29, # 4 p. 259 - 268
